Document Detail


31P MRS studies of exercising human muscle at high temporal resolution.
MedLine Citation:
PMID:  10371446     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Methods for measuring mitochondrial activity from 31P magnetic resonance spectroscopy data collected during and after exercise were compared in controls, weight lifters, and peripheral vascular occlusive disease (PVOD) patients. There were trends toward increasing mitochondrial activity during exercise in order from PVOD patients, moderately active controls, highly active controls, to weight lifters. Results from PVOD patients show divergence of some measures due to 1) the non-exponential nature of phosphocreatine recovery, and 2) potential breakdown of [ADP] control of the mitochondria due to lack of oxygen (for Qmax calculation). These results demonstrate the utility of obtaining and directly analyzing high time resolution data rather than assuming monoexponential behavior of metabolite recovery.
Authors:
M D Boska; J A Nelson; N Sripathi; I I Pipinos; A D Shepard; K M Welch
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine     Volume:  41     ISSN:  0740-3194     ISO Abbreviation:  Magn Reson Med     Publication Date:  1999 Jun 
Date Detail:
Created Date:  1999-07-26     Completed Date:  1999-07-26     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8505245     Medline TA:  Magn Reson Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1145-51     Citation Subset:  IM    
Affiliation:
Department of Neurology, Henry Ford Hospital, Detroit, Michigan, USA.
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MeSH Terms
Descriptor/Qualifier:
Adenosine Diphosphate / biosynthesis
Adenosine Triphosphate / biosynthesis
Case-Control Studies
Energy Metabolism
Humans
Isometric Contraction / physiology*
Magnetic Resonance Imaging / methods
Magnetic Resonance Spectroscopy / diagnostic use,  methods
Mitochondria, Muscle / metabolism
Muscle, Skeletal / chemistry,  metabolism*,  physiology
Peripheral Vascular Diseases / metabolism
Phosphocreatine / biosynthesis
Weight Lifting
Grant Support
ID/Acronym/Agency:
P50-NS32399/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
56-65-5/Adenosine Triphosphate; 58-64-0/Adenosine Diphosphate; 67-07-2/Phosphocreatine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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