| 31P MRS studies of exercising human muscle at high temporal resolution. | |
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MedLine Citation:
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PMID: 10371446 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Methods for measuring mitochondrial activity from 31P magnetic resonance spectroscopy data collected during and after exercise were compared in controls, weight lifters, and peripheral vascular occlusive disease (PVOD) patients. There were trends toward increasing mitochondrial activity during exercise in order from PVOD patients, moderately active controls, highly active controls, to weight lifters. Results from PVOD patients show divergence of some measures due to 1) the non-exponential nature of phosphocreatine recovery, and 2) potential breakdown of [ADP] control of the mitochondria due to lack of oxygen (for Qmax calculation). These results demonstrate the utility of obtaining and directly analyzing high time resolution data rather than assuming monoexponential behavior of metabolite recovery. |
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Authors:
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M D Boska; J A Nelson; N Sripathi; I I Pipinos; A D Shepard; K M Welch |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Volume: 41 ISSN: 0740-3194 ISO Abbreviation: Magn Reson Med Publication Date: 1999 Jun |
Date Detail:
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Created Date: 1999-07-26 Completed Date: 1999-07-26 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8505245 Medline TA: Magn Reson Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1145-51 Citation Subset: IM |
Affiliation:
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Department of Neurology, Henry Ford Hospital, Detroit, Michigan, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Diphosphate
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biosynthesis Adenosine Triphosphate / biosynthesis Case-Control Studies Energy Metabolism Humans Isometric Contraction / physiology* Magnetic Resonance Imaging / methods Magnetic Resonance Spectroscopy / diagnostic use, methods Mitochondria, Muscle / metabolism Muscle, Skeletal / chemistry, metabolism*, physiology Peripheral Vascular Diseases / metabolism Phosphocreatine / biosynthesis Weight Lifting |
| Grant Support | |
ID/Acronym/Agency:
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P50-NS32399/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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56-65-5/Adenosine Triphosphate; 58-64-0/Adenosine Diphosphate; 67-07-2/Phosphocreatine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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