| 31P-MRS demonstrates a reduction in high-energy phosphates in the occipital lobe of migraine without aura patients. | |
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MedLine Citation:
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PMID: 21289000 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background: Differences in brain energy metabolism have been found between migraine patients and controls in previous phosphorus magnetic resonance spectroscopy ((31)P-MRS) studies, most of them emphasizing migraine with aura (MwA). The aim of this study was to verify potential changes in resting-state brain energy metabolism in patients with migraine without aura (MwoA) compared to control subjects by (31)P-MRS at 3 tesla. Methods: Quantification was performed using the phantom replacement technique. MRS measurements were performed interictally and in the medial occipital lobe of 19 MwoA patients and 26 age-matched controls. Results: A significantly decreased phosphocreatine concentration ([PCr]) was found as in previous studies. While adenosine triphosphate concentration ([ATP]) was considered to be constant in previously published work, this study found a significant decrease in the measured [ATP] in MwoA patients. The inorganic phosphate ([P(i)]) and magnesium ([Mg(2+)]) concentrations were not significantly different between MwoA patients and controls. Conclusions: The altered metabolic concentrations indicate that the energy metabolism in MwoA patients is impaired, certainly in a subgroup of patients. The actual decrease in [ATP] adds further strength to the theory of the presence of a mitochondrial component in the pathophysiology of migraine. |
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Authors:
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Harmen Reyngoudt; Koen Paemeleire; Benedicte Descamps; Yves De Deene; Eric Achten |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-2 |
Journal Detail:
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Title: Cephalalgia : an international journal of headache Volume: - ISSN: 1468-2982 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-2-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8200710 Medline TA: Cephalalgia Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Ghent University, Belgium. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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