| 31P-MR spectroscopic imaging in hypertensive heart disease. | |
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MedLine Citation:
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PMID: 16514468 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hypertensive heart disease (HHD) causes structural changes (e.g., fibrosis) that result in diastolic and systolic myocardial dysfunction. Alterations of (31)P metabolism and cardiac energy impairments were assessed in patients with HHD by MR spectroscopy (MRS) and correlated with left ventricular systolic function. Thirty-six patients with HHD and 20 healthy controls (mean age 35.2+/-10.7 years) were examined with (31)P-MRS at 1.5 T by using an ECG-gated CSI sequence. Twenty-five patients (mean age 64.3+/-9.3 years) had diastolic dysfunction, but preserved systolic function (HHD-D), whereas 11 patients (62.3+/-11.4 years) suffered from additional impaired systolic function (HHD-S). In both patient groups, the PCr/gamma-ATP ratio was lower than in the controls (controls: 2.07+/-0.17; P<0.001), and in HHD-S was lower than in HHD-D (1.43+/-0.21 vs. 1.65+/-0.25; P=0.012). PCr/gamma-ATP ratios were linearly correlated with LVEF (Pearson's r: 0.39; P=0.025). In the HHD-S group, the PDE/gamma-ATP ratio was significantly lower (0.56+/-0.36) than in the controls (1.14+/-0.42; P=0.001). In contrast to the group of HHD-D patients, whose slightly decreased PCr/gamma-ATP ratios compared to controls may be explained by age differences, the more distinct changes observed in HHD-S patients indicate an altered energy metabolism. The observed metabolic changes were related to functional impairments, as indicated by a reduced LVEF. Reduced PDE/ATP ratios indicate changes in the phospholipid metabolism. |
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Authors:
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J-P Heyne; R Rzanny; A Hansch; U Leder; J R Reichenbach; W A Kaiser |
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Publication Detail:
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Type: Journal Article Date: 2006-03-02 |
Journal Detail:
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Title: European radiology Volume: 16 ISSN: 0938-7994 ISO Abbreviation: Eur Radiol Publication Date: 2006 Aug |
Date Detail:
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Created Date: 2006-07-10 Completed Date: 2006-11-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9114774 Medline TA: Eur Radiol Country: Germany |
Other Details:
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Languages: eng Pagination: 1796-802 Citation Subset: IM |
Affiliation:
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Institute of Diagnostic and Interventional Radiology, Friedrich Schiller University, Erlanger Allee 101, 07747 Jena, Germany. Jens-Peter.Heyne@med.uni-jena.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Artifacts Case-Control Studies Female Heart Diseases / metabolism* Humans Hypertension / metabolism* Linear Models Magnetic Resonance Spectroscopy / methods* Male Middle Aged Phosphorus Isotopes / diagnostic use Statistics, Nonparametric |
| Chemical | |
Reg. No./Substance:
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0/Phosphorus Isotopes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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