| 311 nm ultraviolet B-accelerated response of psoriatic lesions in adalimumab-treated patients. | |
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MedLine Citation:
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PMID: 21729166 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Treatment with the tumor necrosis factor-alpha antibody adalimumab for 12-16 weeks produces a satisfactory response [i.e., 75% reduction in psoriasis area and severity index (PASI)] in a majority (70-80%) of patients with psoriasis. We asked whether 311 nm ultraviolet B (UVB) can improve therapeutic response of psoriatic lesions to adalimumab. METHODS: Four patients (age range, 49-67 years) with moderate to severe plaque-type psoriasis were treated with standard dosage of adalimumab. During adalimumab therapy, a randomly selected body half (left or right, excluding the head) was irradiated with 311 nm UVB three times weekly for 6 weeks. Treatment response was monitored weekly in terms of half-body PASI. RESULTS: 311 nm UVB significantly accelerated the therapeutic response during adalimumab treatment. At the start of 311 nm UVB therapy, the mean PASI was 14.8. After 6 weeks of 311 nm UVB therapy, the mean PASI was 2.0 on UV-irradiated body halves and 6.9 on non-irradiated body halves (difference, 4.9; 95% confidence interval, 0.4-9.4; P=0.041; 2-tailed paired t-test). This corresponded to an overall mean PASI reduction from baseline (i.e., adalimumab start) of 86% on UV-irradiated body halves vs. 53% on non-irradiated body halves. CONCLUSION: 311 nm UVB may accelerate and improve the clearance of psoriatic lesions in adalimumab-treated patients. |
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Authors:
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Peter Wolf; Angelika Hofer; Wolfgang Weger; Timea Posch-Fabian; Alexandra Gruber-Wackernagel; Franz J Legat |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Photodermatology, photoimmunology & photomedicine Volume: 27 ISSN: 1600-0781 ISO Abbreviation: Photodermatol Photoimmunol Photomed Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-07-06 Completed Date: 2011-11-01 Revised Date: 2013-05-27 |
Medline Journal Info:
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Nlm Unique ID: 9013641 Medline TA: Photodermatol Photoimmunol Photomed Country: Denmark |
Other Details:
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Languages: eng Pagination: 186-9 Citation Subset: IM |
Copyright Information:
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© 2011 John Wiley & Sons A/S. |
Affiliation:
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Research Unit for Photodermatology, Department of Dermatology, Medical University of Graz, Graz, Austria. peter.wolf@meduni.graz.at |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Anti-Inflammatory Agents / administration & dosage* Antibodies, Monoclonal / administration & dosage* Antibodies, Monoclonal, Humanized Combined Modality Therapy Female Humans Male Middle Aged Psoriasis / therapy* Remission Induction Ultraviolet Rays* Ultraviolet Therapy* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Antibodies, Monoclonal; 0/Antibodies, Monoclonal, Humanized; FYS6T7F842/adalimumab |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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