Document Detail


308-nm excimer laser for the treatment of localized vitiligo.
MedLine Citation:
PMID:  12890118     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND OBJECTIVE: Vitiligo is commonly treated with PUVA, and more recently, narrow-band UVB (NBUVB) phototherapy. Given the proximity of the wavelengths of NBUVB (311 nm) and the excimer laser (308 nm), we undertook a clinical trial to test the efficacy of this device. METHODS: Twice-weekly 308-nm UV-B radiation was given to selected vitiligo lesions for a maximum of 60 treatments. These lesions had been unsuccessfully treated previously with at least one other method of treatment. Initial doses were 100 mJ/cm2 with increments of 10-25%. Improvement was assessed on a visual scale via serial photographs. RESULTS: Subjects tolerated the treatment well. Improvement varied with body site. After 60 treatments, lesions on the hands and feet showed grade 2 improvement in 2/10 subjects and grade 1 in 8/10. For the axillae, there was grade 4 improvement in 1/3 subjects and grade 2 improvement in 2/3 by treatment 60. The face demonstrated the most rapid repigmentation with grade 4 repigmentation seen in 3/5 subjects by 40 treatments and grade 3 in 2/5 by 30 treatments. There were no adverse effects. CONCLUSIONS: The user-friendly 308-nm excimer laser allows targeted treatments of localized vitiligo.
Authors:
Atul Taneja; Manju Trehan; Charles R Taylor
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of dermatology     Volume:  42     ISSN:  0011-9059     ISO Abbreviation:  Int. J. Dermatol.     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-07-31     Completed Date:  2004-02-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0243704     Medline TA:  Int J Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  658-62     Citation Subset:  IM    
Affiliation:
Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Female
Humans
Laser Therapy*
Male
Middle Aged
Radiotherapy Dosage
Severity of Illness Index
Skin Pigmentation / radiation effects
Treatment Outcome
Ultraviolet Therapy / instrumentation,  methods*
Vitiligo / pathology*,  radiotherapy*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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