Document Detail

The 301 to 314 amino acid residue of beta-tubulin is not a target epitope for serum IgM antibodies in chronic inflammatory demyelinating polyneuropathy.
MedLine Citation:
PMID:  10223409     Owner:  NLM     Status:  MEDLINE    
Connolly et al. [Neurology 48 (1997) 243] reported that IgM M-proteins from three patients selectively binds to an epitope on beta-tubulin that consists of amino acids 301 to 314. We therefore investigated whether these 14 amino acid residues beta301-314 are the target epitope for serum IgMs in sera from 67 patients with chronic inflammatory demyelinating polyneuropathy (CIDP), 50 with Guillain-Barré syndrome, 50 with motor neuron diseases, and 50 normal controls. IgM anti-beta301-314 antibodies were not restricted to nor were selectively associated with CIDP. We conclude that beta301-314 is not a target epitope for serum IgMs in CIDP.
Y Tagawa; N Yuki; K Hirata
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  163     ISSN:  0022-510X     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  1999 Feb 
Date Detail:
Created Date:  1999-06-10     Completed Date:  1999-06-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  44-6     Citation Subset:  IM    
Department of Neurology, Dokkyo University School of Medicine, Shimotsuga, Tochigi, Japan.
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MeSH Terms
Autoantibodies / blood*
Autoimmune Diseases / blood,  immunology*
Chronic Disease
Demyelinating Diseases / blood,  immunology*
Enzyme-Linked Immunosorbent Assay
Epitopes / chemistry,  immunology*
Immunoglobulin M / blood*
Peripheral Nervous System Diseases / blood,  immunology*
Tubulin / chemistry,  immunology*
Reg. No./Substance:
0/Autoantibodies; 0/Epitopes; 0/Immunoglobulin M; 0/Tubulin

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