Document Detail

30 Hz-flicker mfERG in primary open-angle glaucoma patients : 30 Hz-flicker-mfERG in POAG.
MedLine Citation:
PMID:  16944090     Owner:  NLM     Status:  MEDLINE    
PURPOSE: This study was performed in an attempt to gain more information on whether the 30 Hz-flicker mfERG indeed provides a sensitive measure of dysfunction in patients with primary open-angle glaucoma (POAG) as has been suggested previously. METHODS: Eighteen POAG patients with visual field defects (MD > 2.2 dB) and glaucomatous optic neuropathies as well as 10 control subjects underwent mfERG recording as follows: 30 Hz-flicker mfERG, LED stimulus screen, 61 hexagons, Lmax: 180 cd/m2, Lmin: 0 cd/m2, recording time: approximately 5 min, filter setting: 10-200 Hz. The 30 Hz response (also called the fundamental or the first harmonic response (1HW) and the second harmonic wave at 60 Hz (2HW) were analysed as an overall response and in quadrants, as well as in 4 small neighbouring areas per quadrant. The patients' mfERGs were compared to those of the control group and to the mean defect values (MD) of the corresponding quadrants of the Octopus perimetry. RESULTS: Neither in the overall response, nor in the quadrants, nor in the smaller areas examined did amplitudes and phases of the 1HW and the 2HW or the amplitude ratio of the 2HW to the 1HW (DFT-ratio) differ from the controls (P > 0.05-ANOVA). There was no significant correlation between mfERG values and the MD (Spearman-test, Bonferroni). CONCLUSION: Thus, the 30 Hz-flicker mfERG does not seem to be sensitive enough to separate glaucoma patients from normal.
Margarita G Todorova; Anja M Palmowski-Wolfe; Selim Orguel; Josef Flammer
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-08-30
Journal Detail:
Title:  Documenta ophthalmologica. Advances in ophthalmology     Volume:  113     ISSN:  0012-4486     ISO Abbreviation:  Doc Ophthalmol     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-09-15     Completed Date:  2007-03-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370667     Medline TA:  Doc Ophthalmol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  11-20     Citation Subset:  IM    
Department of Ophthamlology, University Eye Hospital Basel, Mittlere Strasse 91, CH-4012, Basel, Switzerland.
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MeSH Terms
Electroretinography / methods*
Glaucoma, Open-Angle / physiopathology*
Intraocular Pressure
Middle Aged
Optic Nerve Diseases / physiopathology
Retina / physiopathology*
Vision Disorders / physiopathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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