Document Detail

A 3 year, prospectively-designed study of late selective multifetal pregnancy reduction.
MedLine Citation:
PMID:  9740464     Owner:  NLM     Status:  MEDLINE    
The aim of our study was to evaluate the pregnancy outcomes of late selective multifetal reduction (MFPR). We performed a 3 year, prospectively-designed study in which 28 patients underwent MFPR at a mean gestational age of 20.2 +/- 3.9 weeks (range 14-29 weeks). The indications for MFPR included: multiple gestation (> or = 3) (57%), structural anomaly (29%), and chromosomal abnormality (14%). The procedure was performed using ultrasonographically-guided intracardiac injection of potassium chloride. The mean gestational age at delivery was 36.6 +/- 2.2 weeks (range 31-40 weeks). Nine patients (32%) delivered before 36 weeks of gestation. The mean birth weight was 2370 +/- 614 g (range 1510-3250 g). Discordancy was evident in four twins (14%), and intrauterine growth retardation in four pregnancies. One case (3.5%) presented with oligohydramnios, and one with pregnancy-induced hypertension. One case of late abortion due to passive cervical dilatation 4 weeks after the MFPR was observed. Procedure-related amnionitis followed by late abortion occurred in one case. A total of 57% of the patients delivered vaginally and 43% delivered by Caesarean section. We concluded that late selective MFPR is associated with favourable perinatal outcome. Late MFPR may facilitate the detection of structural and chromosomal anomalies prior to the procedure, and the accomplishment of selective reduction of the affected fetus.
J Hartoov; E Geva; I Wolman; L Lerner-Geva; J B Lessing; R Amster; A Amit; A Jaffa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  13     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  1998 Jul 
Date Detail:
Created Date:  1998-11-17     Completed Date:  1998-11-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1996-8     Citation Subset:  IM    
Ultrasound Unit, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, Israel.
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MeSH Terms
Abortion, Spontaneous / etiology
Birth Weight
Chorioamnionitis / etiology
Chromosome Aberrations*
Congenital Abnormalities* / diagnosis
Gestational Age*
Potassium Chloride / administration & dosage
Pregnancy Complications
Pregnancy Outcome*
Pregnancy Reduction, Multifetal* / adverse effects
Pregnancy, Multiple*
Prenatal Diagnosis
Prospective Studies
Reg. No./Substance:
7447-40-7/Potassium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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