| A 3-year intervention with a Mediterranean diet modified the association between the rs9939609 gene variant in FTO and body weight changes. | |
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MedLine Citation:
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PMID: 19918250 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: The aim of this study was to analyze the effects of the rs9939609 (T/A) gene variant in fat mass and obesity-associated gene (FTO) on body weight changes after 3 years and its modification by a randomized nutritional intervention with a Mediterranean-style diet in a population of subjects at high cardiovascular risk. DESIGN: A substudy of PREDIMED, which is a randomized trial aimed at assessing the effect of the Mediterranean diet (MD) for primary cardiovascular disease prevention. There were three nutritional intervention groups: two of them with a Mediterranean-style diet and the third was a control group advised to follow a conventional low-fat diet. SUBJECTS: A total of 776 high cardiovascular risk subjects aged 55-80 years. MEASUREMENTS: Anthropometric measurements were recorded at baseline and at 3 years. The participants were genotyped by RT-PCR, followed by allelic discrimination. RESULTS: Homozygous subjects had the highest baseline body weight. The dominant model showed that subjects carrying the A allele had the lowest body weight gain (B=-0.685; P=0.022) after 3 years of nutritional intervention compared with nonmutated subjects (TT genotype) regardless of the nutritional intervention. Moreover, this effect was statistically significant in carriers of the A allele only among those allocated to the MD groups (B=-0.830; P=0.018), but it was not significant among those allocated to the control group (P for interaction=0.649). CONCLUSION: This study confirmed the association between body weight and the FTO rs9939609 polymorphism. Interestingly, our results showed that, although at baseline the A allele was associated with higher body weight, after 3 years of nutritional intervention with a Mediterranean-style-diet, A-allele carriers had lower body weight gain than wild type subjects. No interaction between nutritional intervention and the polymorphism was found. |
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Authors:
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C Razquin; J A Martinez; M A Martinez-Gonzalez; M Bes-Rastrollo; J Fernández-Crehuet; A Marti |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2009-11-17 |
Journal Detail:
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Title: International journal of obesity (2005) Volume: 34 ISSN: 1476-5497 ISO Abbreviation: Int J Obes (Lond) Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-15 Completed Date: 2010-11-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101256108 Medline TA: Int J Obes (Lond) Country: England |
Other Details:
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Languages: eng Pagination: 266-72 Citation Subset: IM |
Affiliation:
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Department of Nutrition and Food Sciences, Physiology and Toxicology, University of Navarra, Navarra, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Body Mass Index Body Weight / genetics* Cardiovascular Diseases / diet therapy, genetics*, prevention & control Diet, Fat-Restricted Diet, Mediterranean* Female Genetic Variation / genetics Genotype Humans Male Middle Aged Obesity / diet therapy, genetics* Proteins / genetics* Time Factors Treatment Outcome Weight Gain / genetics |
| Chemical | |
Reg. No./Substance:
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0/FTO protein, human; 0/Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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