Document Detail


3D model of frequency representation in the cochlear nucleus of the CBA/J mouse.
MedLine Citation:
PMID:  23047723     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The relationship between structure and function is an invaluable context with which to explore biological mechanisms of normal and dysfunctional hearing. The systematic and topographic representation of frequency originates at the cochlea, and is retained throughout much of the central auditory system. The cochlear nucleus (CN), which initiates all ascending auditory pathways, represents an essential link for understanding frequency organization. A model of the CN that maps frequency representation in 3D would facilitate investigations of possible frequency specializations and pathologic changes that disturb frequency organization. Toward this goal, we reconstructed in 3D the trajectories of labeled auditory nerve (AN) fibers following multiunit recordings and dye injections in the anteroventral CN of the CBA/J mouse. We observed that each injection produced a continuous sheet of labeled AN fibers. Individual cases were normalized to a template using 3D alignment procedures that revealed a systematic and tonotopic arrangement of AN fibers in each subdivision with a clear indication of isofrequency laminae. The combined dataset was used to mathematically derive a 3D quantitative map of frequency organization throughout the entire volume of the CN. This model, available online (http://3D.ryugolab.com/), can serve as a tool for quantitatively testing hypotheses concerning frequency and location in the CN.
Authors:
Michael A Muniak; Alejandro Rivas; Karen L Montey; Bradford J May; Howard W Francis; David K Ryugo
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The Journal of comparative neurology     Volume:  521     ISSN:  1096-9861     ISO Abbreviation:  J. Comp. Neurol.     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-03-19     Completed Date:  2013-08-26     Revised Date:  2014-06-24    
Medline Journal Info:
Nlm Unique ID:  0406041     Medline TA:  J Comp Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1510-32     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
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MeSH Terms
Descriptor/Qualifier:
Acoustic Stimulation
Animals
Cochlear Nerve / anatomy & histology,  physiology
Cochlear Nucleus / anatomy & histology*,  physiology
Electrophysiology
Female
Imaging, Three-Dimensional*
Male
Mice
Mice, Inbred CBA
Grant Support
ID/Acronym/Agency:
DC00023/DC/NIDCD NIH HHS; DC00143/DC/NIDCD NIH HHS; DC00232/DC/NIDCD NIH HHS; DC04395/DC/NIDCD NIH HHS; DC05211/DC/NIDCD NIH HHS; DC05909/DC/NIDCD NIH HHS; K08 DC000143/DC/NIDCD NIH HHS; P30 DC005211/DC/NIDCD NIH HHS; R01 DC000232/DC/NIDCD NIH HHS; R01 DC004395/DC/NIDCD NIH HHS; R03 DC005909/DC/NIDCD NIH HHS; T32 DC000023/DC/NIDCD NIH HHS
Comments/Corrections

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