| 3 Tesla MRI-Detected Brain Lesions after Pulmonary Vein Isolation for Atrial Fibrillation: Results of the MACPAF Study. | |
| | |
MedLine Citation:
|
PMID: 22913568 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
MRI Results of the MACPAF Study. Background: Left atrial catheter ablation (LACA) is an established therapeutic approach to abolish symptomatic atrial fibrillation (AF). Objective: Based on the prospective MACPAF study (clinicaltrials.gov NCT01061931) we report the rate of ischemic brain lesions postablation and their impact on cognitive function. Methods: Patients with symptomatic paroxysmal AF were randomized to LACA using the Arctic Front® or the HD Mesh Ablator® catheter. All patients underwent brain MRI at 3 Tesla, neurological, and neuropsychological examinations within 48 hours prior and after the ablation procedure. Results: There was no clinically evident stroke in 37 patients (mean age 62.4 ± 8.4 years; 41% female; median CHADS2 score 1 [IQR 0-2]) after LACA but high-resolution diffusion-weighted imaging (DWI) detected new ischemic lesions in 15 (41%) patients after LACA. Four (27%) of the HD Mesh Ablator® patients and 11 (50%) of the Arctic Front® patients suffered a silent ischemic lesion (P = 0.19). In these 15 patients, there was a nonsignificant trend toward lower cardiac ejection fraction (P = 0.07) and AF episodes during LACA (P = 0.09), while activated clotting time levels, number of energy applications, periprocedural electrocardioversion or CHADS(2) score had no impact. Lesion volumes varied from 5 to 150 mm(3) and 1 to 5 lesions were detected per patient. However, acute brain lesions had no effect on cognitive performance immediately after LACA. Of the DWI lesions postablation 82% were not detectable on FLAIR images 6-9 months postablation. Conclusions: According to 3 Tesla high-resolution DWI, ischemic brain lesions after LACA were common but not associated with impaired cognitive function after the ablation procedure. (J Cardiovasc Electrophysiol, Vol. pp. 1-8). |
| | |
Authors:
|
Karl Georg Haeusler; Lydia Koch; Juliane Herm; Ute A Kopp; Peter U Heuschmann; Matthias Endres; Heinz-Peter Schultheiss; Alexander Schirdewan; Jochen B Fiebach |
Related Documents
:
|
8491688 - Static and dynamic vascular impact of large artery irradiation. 17171098 - Harvesting large fascia lata sheaths: a rational approach. 22659718 - Cortical excitability in migraine and epilepsy: a common feature? 22506118 - Evaluation of serum biomarkers for patients at increased risk of stroke. 19392598 - Characteristics of auras in patients undergoing temporal lobectomy. 10371388 - Electroclinical characteristics of hemimegalencephaly. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-7-25 |
Journal Detail:
|
Title: Journal of cardiovascular electrophysiology Volume: - ISSN: 1540-8167 ISO Abbreviation: J. Cardiovasc. Electrophysiol. Publication Date: 2012 Jul |
Date Detail:
|
Created Date: 2012-8-23 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9010756 Medline TA: J Cardiovasc Electrophysiol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
© 2012 Wiley Periodicals, Inc. |
Affiliation:
|
Department of Neurology, Charité-Universitätsmedizin Berlin, Germany Center for Stroke Research Berlin, Charité-Universitätsmedizin Berlin, Germany Department of Cardiology and Pneumology, Charité-Universitätsmedizin Berlin, Germany Institute of Clinical Epidemiology and Biometry-Universität Würzburg, Germany Center for Clinical Studies, University Hospital Würzburg Comprehensive Heart Failure Center, University of Würzburg, Germany Excellence Cluster NeuroCure, Charité-Universitätsmedizin Berlin, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Elevated levels of circulating IL-18BP and perturbed regulation of IL-18 in schizophrenia.
Next Document: Dual influence of spontaneous hypertension on membrane properties and ATP production in heart and ki...