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3-Hydroxykynurenine: an intriguing molecule exerting dual actions in the Central Nervous System.
MedLine Citation:
PMID:  23219925     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Kynurenine pathway is gaining attention because of the many metabolic processes in which it has been involved. The tryptophan conversion into several other metabolites through this pathway provides neuronal and redox modulators useful for maintenance of major functions in the brain. However, when physiopathological conditions prevail -i.e. oxidative stress, excitotoxicity and inflammation-, preferential formation and accumulation of toxic metabolites could trigger factors for degeneration in neurological disorders. 3-Hydroxykynurenine has been largely described as one of these toxic metabolites capable of inducing oxidative damage and cell death; consequently, this metabolite has been hypothesized to play a pivotal role in different neurological and psychiatric disorders. Supporting evidence has shown altered 3-hydroxykynurenine levels in samples of patients from several disorders. In contrast, some experimental studies have provided evidence on antioxidant and scavenging properties inherent to this molecule. In this review, we explored most of literature favoring one or the other concept, in order to provide an accurate vision on the real participation of this tryptophan metabolite in both experimental paradigms and human brain pathologies. Through this collected evidence, we provide an integrative hypothesis on how 3-hydroxykynurenine is exerting its dual actions in the Central Nervous System and what will be the course of investigations in this field for the next years.
Authors:
Ana Laura Colín-González; Perla D Maldonado; Abel Santamaría
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-3
Journal Detail:
Title:  Neurotoxicology     Volume:  -     ISSN:  1872-9711     ISO Abbreviation:  Neurotoxicology     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7905589     Medline TA:  Neurotoxicology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier B.V.
Affiliation:
Laboratorio de Aminoácidos Excitadores, Instituto Nacional de Neurología y Neurocirugía. Mexico City 14269, Mexico; Laboratorio de Patología Vascular Cerebral, Instituto Nacional de Neurología y Neurocirugía. Mexico City 14269, Mexico.
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