Document Detail


3-Hydroxy-3-methylglutaryl--coenzyme A reductase inhibitors in the treatment of hypercholesterolemia.
MedLine Citation:
PMID:  3316727     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A new class of drugs, which inhibit de novo cholesterol biosynthesis, significantly reduces the blood cholesterol concentrations in hypercholesterolemic patients. Four separate inhibitors have lowered plasma total cholesterol and low-density lipoprotein (LDL) levels in humans by 20% to 40%: mevastatin (Compactin), lovastatin (mevinolin), pravastatin (CS-514, Eptastatin, and SQ 31000), and simvastatin (Synvinolin, MK-733). In addition to lowering total and LDL cholesterol concentrations, the plasma concentration of the potentially atherogenic B apolipoprotein is also reduced by 20% to 40%. The reduction in the levels of circulating atherogenic lipoprotein particles occurs as a result of decreased synthesis and enhanced removal of LDLs by the LDL receptor pathway in hepatocytes. Moreover, the levels of high-density lipoprotein cholesterol, which are inversely related to atherosclerosis, increase in concentration with treatment by these drugs. If the short-term safety of these drugs extends to ongoing long-term studies and if cardiovascular morbidity and mortality are affected by their use, this class of hypolipidemic agent will markedly facilitate the effective treatment of hypercholesterolemia.
Authors:
J M Hoeg; H B Brewer
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  JAMA     Volume:  258     ISSN:  0098-7484     ISO Abbreviation:  JAMA     Publication Date:  1987 Dec 
Date Detail:
Created Date:  1988-01-14     Completed Date:  1988-01-14     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  7501160     Medline TA:  JAMA     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  3532-6     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Animals
Anticholesteremic Agents / adverse effects,  therapeutic use*
Child
Cholesterol, LDL / blood
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors*
Hypercholesterolemia / drug therapy*
Lovastatin / therapeutic use
Chemical
Reg. No./Substance:
0/Anticholesteremic Agents; 0/Cholesterol, LDL; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 9LHU78OQFD/Lovastatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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