Document Detail


3-D ultrastructural distribution of collagen in human placental villi at term in relation to vascular tree.
MedLine Citation:
PMID:  15846046     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In order to understand the 3-D distribution of collagen in relation to vascularization, chorionic villi of human placentae, belonging to normal pregnancies at term, were studied by scanning electron microscopy (SEM) after alkali maceration techniques, and by transmission electron microscopy (TEM). The villous tree appeared made of an uninterrupted structure of collagen fibres. The collagen fibres connected the chorionic villi axis with their basal plates and organised differently according to the various levels of villous branching. The collagen of stem villi showed copious fibres. The external fibres (facing the villous surface) were arranged mainly longitudinally. The central core of the villi (inner fibres) were arranged concentrically around the wall of the fetal vessels. Both external and internal fibres formed stratified lamellae or small parallel bundles. The inner core of stem villi showed small holes housing capillary spaces. Mature intermediate and terminal villi showed a scarce amount of collagen arranged in thin concentric layer within the villous core, surrounding numerous dilated capillary and sinusoid spaces.These observations demonstrated that the extracellular matrix of human chorionic villi is highly compartmentalised and shows a variable structural 3-D distribution depending on the branching level of the villous tree, such a distribution ensures the most favourable microenvironment for feto-maternal exchanges and it is likely able to provide a modulated support to the developing chorionic fetal vessels and trophoblastic layer as well.
Authors:
Enrico Vizza; Silvia Correr; Fabrizio Barberini; Rosemarie Heyn; Serena Bianchi; Guido Macchiarelli
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-04-22
Journal Detail:
Title:  The Journal of reproduction and development     Volume:  51     ISSN:  0916-8818     ISO Abbreviation:  J. Reprod. Dev.     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-09-05     Completed Date:  2006-08-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9438792     Medline TA:  J Reprod Dev     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  433-43     Citation Subset:  IM    
Affiliation:
Gynaecologic Endoscopy and Minimally Invasive Surgery Unit, Division of Gynaecologic Oncology, National Cancer Institute Regina Elena, Rome, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adult
Chorionic Villi / metabolism
Collagen / biosynthesis*,  chemistry,  metabolism
Extracellular Matrix / metabolism
Female
Freezing
Humans
Imaging, Three-Dimensional / methods*
Maternal-Fetal Exchange
Microscopy, Electron, Scanning
Microscopy, Electron, Transmission
Neovascularization, Pathologic
Placenta / blood supply*,  metabolism,  ultrastructure*
Pregnancy
Sodium Hydroxide / pharmacology
Trophoblasts / metabolism
Chemical
Reg. No./Substance:
1310-73-2/Sodium Hydroxide; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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