Document Detail

3-Aminobenzamide induces cytoskeleton rearrangement in M14 melanoma cells.
MedLine Citation:
PMID:  8048965     Owner:  NLM     Status:  MEDLINE    
3-aminobenzamide (3-ABA) is an inhibitor of poly-ADP-ribose-polymerase, an enzyme involved in numerous subcellular processes including cell death. With the aim of contributing to clarify the mode of action of the drug, which is still poorly understood, its effects on cultured melanoma cells M14 have been assessed. In particular, an impairment of cell growth accompanied by the formation of long and numerous dendritic-like protrusions has been detected. This finding appears to be due to a specific effect of the drug on some cytoskeletal elements and could be associated with its differentiating capability. This finding, together with previous data from our group--Biochem. Biophys. Res. Commun., (1994) 199, 525-530 and 1250-1255--suggests that cytoskeleton is an important target of 3-ABA.
W Malorni; G Rainaldi; E Straface; R Rivabene; A Cossarizza; M Capri; D Monti; C Franceschi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  202     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1994 Jul 
Date Detail:
Created Date:  1994-09-01     Completed Date:  1994-09-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  915-22     Citation Subset:  IM    
Department of Ultrastructures, Istituto Superiore di Sanità, Roma, Italy.
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MeSH Terms
Benzamides / pharmacology*
Cell Division / drug effects
Cytoskeleton / drug effects,  ultrastructure*
Melanoma / ultrastructure*
Microscopy, Electron, Scanning
Microscopy, Fluorescence
Poly(ADP-ribose) Polymerases / antagonists & inhibitors
Tumor Cells, Cultured
Reg. No./Substance:
0/Benzamides; 3544-24-9/3-aminobenzamide; EC Polymerases

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