| 3-4-Methylenedioxymethamphetamine-induced acute changes in dopamine transporter function. | |
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MedLine Citation:
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PMID: 9671099 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The acute effects of the amphetamine designer drug, 3,4-methylenedioxymethamphetamine (MDMA or 'ecstasy'), on dopamine transporter function in rat striatum were investigated and compared to other psychostimulants known to influence monoaminergic systems. A single MDMA injection (10-20 mg/kg; s.c.) caused a dose-related decrease in [3H]dopamine uptake into striatal synaptosomes prepared 1 h after MDMA administration. This rapid effect on [3H]dopamine uptake returned to control levels 24 h after treatment. A single administration of other amphetamine analogs, such as methamphetamine (15 mg/kg; s.c.), p-chloroamphetamine (10 mg/kg; i.p.) or methcathinone (30 mg/kg; s.c.), also rapidly decreased striatal [3H]dopamine uptake. In contrast, a single or multiple administrations of cocaine (30 mg/kg; i.p.) had no effect on [3H]dopamine transport into striatal synaptosomes. These changes in dopamine transporter activity by the amphetamine analogs may occur via reactive oxygen species-mediated mechanisms. |
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Authors:
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R R Metzger; G R Hanson; J W Gibb; A E Fleckenstein |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: European journal of pharmacology Volume: 349 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 1998 May |
Date Detail:
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Created Date: 1998-09-23 Completed Date: 1998-09-23 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 205-10 Citation Subset: IM |
Affiliation:
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Department of Pharmacology and Toxicology, University of Utah, Salt Lake City 84112, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carrier Proteins / physiology* Cocaine / pharmacology Dopamine / metabolism* Dopamine Plasma Membrane Transport Proteins Hallucinogens / pharmacology* Male Membrane Glycoproteins* Membrane Transport Proteins* Methamphetamine / pharmacology N-Methyl-3,4-methylenedioxyamphetamine / pharmacology* Neostriatum / drug effects*, physiology Nerve Tissue Proteins* Propiophenones / pharmacology Rats Rats, Sprague-Dawley Synaptosomes / drug effects*, physiology |
| Grant Support | |
ID/Acronym/Agency:
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DA 00869/DA/NIDA NIH HHS; DA 04222/DA/NIDA NIH HHS; DA 11389/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Carrier Proteins; 0/Dopamine Plasma Membrane Transport Proteins; 0/Hallucinogens; 0/Membrane Glycoproteins; 0/Membrane Transport Proteins; 0/Nerve Tissue Proteins; 0/Propiophenones; 42542-10-9/N-Methyl-3,4-methylenedioxyamphetamine; 50-36-2/Cocaine; 537-46-2/Methamphetamine; 5650-44-2/monomethylpropion |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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