| The 2nd Berlin BedRest Study: protocol and implementation. | |
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MedLine Citation:
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PMID: 20811145 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Long-term bed-rest is used to simulate the effect of spaceflight on the human body and test different kinds of countermeasures. The 2nd Berlin BedRest Study (BBR2-2) tested the efficacy of whole-body vibration in addition to high-load resisitance exercise in preventing bone loss during bed-rest. Here we present the protocol of the study and discuss its implementation. Twenty-four male subjects underwent 60-days of six-degree head down tilt bed-rest and were randomised to an inactive control group (CTR), a high-load resistive exercise group (RE) or a high-load resistive exercise with whole-body vibration group (RVE). Subsequent to events in the course of the study (e.g. subject withdrawal), 9 subjects participated in the CTR-group, 7 in the RVE-group and 8 (7 beyond bed-rest day-30) in the RE-group. Fluid intake, urine output and axiallary temperature increased during bed-rest (p < .0001), though similarly in all groups (p > or = .17). Body weight changes differed between groups (p < .0001) with decreases in the CTR-group, marginal decreases in the RE-group and the RVE-group displaying significant decreases in body-weight beyond bed-rest day-51 only. In light of events and experiences of the current study, recommendations on various aspects of bed-rest methodology are also discussed. |
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Authors:
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D L Belavý; O Bock; H Börst; G Armbrecht; U Gast; C Degner; G Beller; H Soll; M Salanova; H Habazettl; M Heer; A de Haan; D F Stegeman; P Cerretelli; D Blottner; J Rittweger; C Gelfi; U Kornak; D Felsenberg |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of musculoskeletal & neuronal interactions Volume: 10 ISSN: 1108-7161 ISO Abbreviation: J Musculoskelet Neuronal Interact Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101084496 Medline TA: J Musculoskelet Neuronal Interact Country: Greece |
Other Details:
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Languages: eng Pagination: 207-19 Citation Subset: IM |
Affiliation:
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Charité Universitatsmedizin Berlin, Center of Muscle and Bone Research, Hindenburgdamm 30, 12203 Berlin, Germany. belavy@gmail.com |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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