| 2H and 31P NMR study of pentalysine interaction with headgroup deuterated phosphatidylcholine and phosphatidylserine. | |
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MedLine Citation:
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PMID: 3240757 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The interaction of cationic pentalysine with phospholipid membranes was studied by using phosphorus and deuterium Nuclear Magnetic Resonance (NMR) of headgroup deuterated dimyristoyl phosphatidylcholine (DMPC) and dimyristoyl phosphatidylserine (DMPS). In the absence of pentalysine, some of the deuterium and phosphorus spectra of DMPC/DMPS 5:1 (m:m) membranes gave lineshapes similar to those of partially-oriented bilayers with the planes of the bilayers being parallel to the magnetic field. The deuterium NMR data show that the quadrupolar splittings of the deuterated methylenes of the DMPC headgroup are not affected by adsorption of pentalysine on the PC/PS membranes. By contrast, the pentalysine produces significant changes in the quadrupolar splittings of the negatively charged DMPS headgroup. The results are discussed in relation to previous 2H NMR investigations of phospholipid headgroup perturbations arising from bilayer interaction with cationic molecules. |
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Authors:
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M Roux; J M Neumann; M Bloom; P F Devaux |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European biophysics journal : EBJ Volume: 16 ISSN: 0175-7571 ISO Abbreviation: Eur. Biophys. J. Publication Date: 1988 |
Date Detail:
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Created Date: 1989-05-19 Completed Date: 1989-05-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8409413 Medline TA: Eur Biophys J Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 267-73 Citation Subset: IM |
Affiliation:
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Département de Biologie, Service de Biophysique, CEN-Saclay, Gif-sur-Yvette, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Deuterium Dimyristoylphosphatidylcholine* Magnetic Resonance Spectroscopy Oligopeptides* Phosphatidylserines* |
| Chemical | |
Reg. No./Substance:
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0/Oligopeptides; 0/Phosphatidylserines; 13699-48-4/Dimyristoylphosphatidylcholine; 19431-21-1/pentalysine; 64023-32-1/dimyristoylphosphatidylserine; 7782-39-0/Deuterium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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