Document Detail

2H and 31P NMR study of pentalysine interaction with headgroup deuterated phosphatidylcholine and phosphatidylserine.
MedLine Citation:
PMID:  3240757     Owner:  NLM     Status:  MEDLINE    
The interaction of cationic pentalysine with phospholipid membranes was studied by using phosphorus and deuterium Nuclear Magnetic Resonance (NMR) of headgroup deuterated dimyristoyl phosphatidylcholine (DMPC) and dimyristoyl phosphatidylserine (DMPS). In the absence of pentalysine, some of the deuterium and phosphorus spectra of DMPC/DMPS 5:1 (m:m) membranes gave lineshapes similar to those of partially-oriented bilayers with the planes of the bilayers being parallel to the magnetic field. The deuterium NMR data show that the quadrupolar splittings of the deuterated methylenes of the DMPC headgroup are not affected by adsorption of pentalysine on the PC/PS membranes. By contrast, the pentalysine produces significant changes in the quadrupolar splittings of the negatively charged DMPS headgroup. The results are discussed in relation to previous 2H NMR investigations of phospholipid headgroup perturbations arising from bilayer interaction with cationic molecules.
M Roux; J M Neumann; M Bloom; P F Devaux
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European biophysics journal : EBJ     Volume:  16     ISSN:  0175-7571     ISO Abbreviation:  Eur. Biophys. J.     Publication Date:  1988  
Date Detail:
Created Date:  1989-05-19     Completed Date:  1989-05-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8409413     Medline TA:  Eur Biophys J     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  267-73     Citation Subset:  IM    
Département de Biologie, Service de Biophysique, CEN-Saclay, Gif-sur-Yvette, France.
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MeSH Terms
Magnetic Resonance Spectroscopy
Reg. No./Substance:
0/Oligopeptides; 0/Phosphatidylserines; 13699-48-4/Dimyristoylphosphatidylcholine; 19431-21-1/pentalysine; 64023-32-1/dimyristoylphosphatidylserine; 7782-39-0/Deuterium

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