| 2D label-free imaging of resonant grating biochips in ultraviolet. | |
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MedLine Citation:
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PMID: 20589008 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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2D images of label-free biochips exploiting resonant waveguide grating (RWG) are presented. They indicate sensitivities on the order of 1 pg/mm2 for proteins in air, and hence 10 pg/mm2 in water can be safely expected. A 320x256 pixels Aluminum-Gallium-Nitride-based sensor array is used, with an intrinsic narrow spectral window centered at 280 nm. The additional role of characteristic biological layer absorption at this wavelength is calculated, and regimes revealing its impact are discussed. Experimentally, the resonance of a chip coated with protein is revealed and the sensitivity evaluated through angular spectroscopy and imaging. In addition to a sensitivity similar to surface plasmon resonance (SPR), the RWGs resonance can be flexibly tailored to gain spatial, biochemical, or spectral sensitivity. |
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Authors:
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K Bougot-Robin; J-L Reverchon; M Fromant; L Mugherli; P Plateau; H Benisty |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Optics express Volume: 18 ISSN: 1094-4087 ISO Abbreviation: Opt Express Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-06-30 Completed Date: 2010-11-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101137103 Medline TA: Opt Express Country: United States |
Other Details:
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Languages: eng Pagination: 11472-82 Citation Subset: IM |
Affiliation:
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Thales Research & Technology, 1 avenue Fresnel, Campus Polytechnique, 91767 Palaiseau, France. kristelle_robin@yahoo.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biosensing Techniques
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instrumentation* Equipment Design Equipment Failure Analysis Protein Array Analysis / instrumentation* Refractometry / instrumentation* Staining and Labeling Surface Plasmon Resonance / instrumentation* Transducers* Ultraviolet Rays |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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