| The 29 kDa light chain that regulates axonemal dynein activity binds to cytoplasmic dyneins. | |
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MedLine Citation:
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PMID: 9453709 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In earlier studies, Hamasaki et al. (Proc. Natl. Acad. Sci. USA. 88:7918-7922, 1991) and Barkalow et al. (J. Cell Biol. 126:727-735, 1994) found that cAMP- and Ca2+-sensitive phosphorylation of a 29 kDa dynein light chain (p29) extracted from 22S axonemal dynein of Paramecium, regulates the velocity of in vitro microtubule translocation and ciliate swimming speed. In this study we report evidence of recombination of p29 to cytoplasmic dyneins from both rat liver and Paramecium, as well as to a 22S dynein precursor molecule, based on immunoprecipitation and force filtration data. Immunoprecipitation also provides additional evidence for the binding of p29 to 22S axonemal dynein. The results suggest that p29 might regulate cytoplasmic dynein, as well as axonemal dynein function in Paramecium, and that a homologue of p29 may exist in rat liver and other mammalian cells. |
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Authors:
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H Wang; P Satir |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Cell motility and the cytoskeleton Volume: 39 ISSN: 0886-1544 ISO Abbreviation: Cell Motil. Cytoskeleton Publication Date: 1998 |
Date Detail:
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Created Date: 1998-02-12 Completed Date: 1998-02-12 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 8605339 Medline TA: Cell Motil Cytoskeleton Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1-8 Citation Subset: IM |
Affiliation:
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Department of Anatomy and Structural Biology, Albert Einstein College of Medicine Bronx, New York 10461, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibodies Cytoskeleton / enzymology*, metabolism* Dyneins / immunology, metabolism* Electrophoresis, Polyacrylamide Gel Enzyme Activation Hot Temperature Male Molecular Weight Paramecium Precipitin Tests Protein Binding Rats Rats, Sprague-Dawley Ultracentrifugation Ultrafiltration |
| Grant Support | |
ID/Acronym/Agency:
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CA09475/CA/NCI NIH HHS; DK41296/DK/NIDDK NIH HHS; DK41918/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antibodies; EC 3.6.4.2/Dyneins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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