Document Detail

28K antigen in the urothelium.
MedLine Citation:
PMID:  1569693     Owner:  NLM     Status:  MEDLINE    
We have been investigating the nature of the mucosal lining of human urinary bladder. Surface material was obtained from bladders at autopsy and used for biochemical analysis. Western immunoblotting and tissue immunochemistry identified a molecule of Mr 28,000 (28K) which is present within surface cells of the urothelium (umbrella cells). Antiserum to 28K stained sections of the bladder of two patients with squamous cell carcinoma of the bladder and other patients with squamous metaplasia. We consider 28K to be a component of the normal human bladder surface that is increased in patients with squamous metaplasia and may also be present in squamous cell carcinoma of the bladder.
J Z Montgomerie; A J Keyser; H J Holshuh; D G Schick
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of urology     Volume:  147     ISSN:  0022-5347     ISO Abbreviation:  J. Urol.     Publication Date:  1992 May 
Date Detail:
Created Date:  1992-05-26     Completed Date:  1992-05-26     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376374     Medline TA:  J Urol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1388-90     Citation Subset:  AIM; IM    
Department of Medicine, University of Southern California School of Medicine, Los Angeles.
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MeSH Terms
Antigens / analysis*
Carcinoma, Squamous Cell / chemistry*
Epithelium / chemistry
Urinary Bladder / chemistry*
Urinary Bladder Neoplasms / chemistry*
Grant Support
Reg. No./Substance:

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