Document Detail


On the 28-gon symmetry inherent in the genetic code intertwined with aminoacyl-tRNA synthetases--the Lucas series.
MedLine Citation:
PMID:  15294424     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Despite considerable efforts it has remained unclear what principle governs the selection of the 20 canonical amino acids in the genetic code. Based on a previous study of the 28-gonal and rotational symmetric arrangement of the 20 amino acids in the genetic code, new analyses of the organization of the genetic code system together with their intrinsic relation to the two classes of aminoacyl-tRNA synthetases are reported in this work. A close inspection revealed how the enzymes and the 20 gene-encoded amino acids are intertwined on the polyhedron model. Complementary and cooperative symmetries between class I and class II aminoacyl-tRNA synthetases displayed by a 28-gon organization are discussed, and we found that the two previously suggested evolutionary axes within the genetic code overlap the symmetry axes within the two classes of aminoacyl-tRNA synthetases. Moreover, it has been shown that the side-chain carbon-atom numbers (2, 1, 3, 4 and 7) in the overwhelming majority of the amino acids recognized by each of the two classes of aminoacyl-tRNA synthetases are determined by a mathematical relationship, the Lucas series. A stepwise co-evolutionary selection logic of the amino acids is manifested by the amino acid side-chain carbon-atom number balance at '17', when grouping the genetic code doublets in the 28-gon organization. The number '17' equals the sum of the initial five numbers in the Lucas series, which are 2, 1, 3, 4 and 7.
Authors:
Chi Ming Yang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bulletin of mathematical biology     Volume:  66     ISSN:  0092-8240     ISO Abbreviation:  Bull. Math. Biol.     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-08-05     Completed Date:  2005-06-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401404     Medline TA:  Bull Math Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1241-57     Citation Subset:  IM    
Affiliation:
Physical Organic Chemistry and Chemical Biology, Neurochemistry and System Chemical Biology Program, Nankai University, Tian Jin 300071, China. yangchm@nankai.edu.cn
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MeSH Terms
Descriptor/Qualifier:
Amino Acids / genetics*
Amino Acyl-tRNA Synthetases / genetics*
Evolution, Molecular*
Genetic Code / genetics*
Humans
Models, Genetic*
Chemical
Reg. No./Substance:
0/Amino Acids; EC 6.1.1.-/Amino Acyl-tRNA Synthetases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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