Document Detail

28-Day oral toxicity study in rats with high purity barley beta-glucan (Glucagel).
MedLine Citation:
PMID:  19879311     Owner:  NLM     Status:  MEDLINE    
Beta-glucans are glucose polymers present in cereal grains, particularly barley and oat. Consumption of these grains or concentrated beta-glucan preparations has been shown to lower blood cholesterol. The present study was conducted to assess the safety of a high purity (>75%) barley beta-glucan (Glucagel). The product was fed to Wistar rats (5/sex/group) at dietary levels of 0% (control), 1%, 5% and 10% for 28 days. Clinical and neurobehavioural observations, growth, feed and water consumption, ophthalmoscopy, haematology, clinical chemistry, urinalysis, organ weights, necropsy and histopathological examination revealed no adverse effects of Glucagel. High-dose males exhibited lower plasma cholesterol and phospholipids levels and a higher plasma urea level. These slight changes were considered of no toxicological significance. Full and empty caecum weights were increased in mid- and high-dose males. This caecal enlargement was a physiological response to the consumption of a high amount of indigestible carbohydrate and considered of no toxicological concern. In conclusion, feeding Glucagel at dietary levels up to 10% for 28 days was tolerated without any signs of toxicity. This dietary level was equivalent to 7.7 g Glucagel (5.8 g beta-glucan)/kg body weight/day in male rats and 7.8 g Glucagel (5.9 g beta-glucan)/kg body weight/day in female rats.
D Jonker; O Hasselwander; A Tervil?-Wilo; P P Tenning
Publication Detail:
Type:  Journal Article     Date:  2009-10-29
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  48     ISSN:  1873-6351     ISO Abbreviation:  Food Chem. Toxicol.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-02-01     Completed Date:  2010-04-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  422-8     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Elsevier Ltd. All rights reserved.
TNO Quality of Life, Utrechtseweg 48, 3704 HE Zeist, The Netherlands.
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MeSH Terms
Administration, Oral
Animal Feed / analysis
Behavior, Animal / drug effects
Blood Cell Count
Body Weight / drug effects
Dose-Response Relationship, Drug
Eating / drug effects
Eye Diseases / chemically induced,  pathology
Hordeum / chemistry*
Organ Size / drug effects
Rats, Wistar
beta-Glucans / toxicity*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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