| A 28-day oral dose toxicity study in Wistar rats enhanced to detect endocrine effects of decabromodiphenyl ether (decaBDE). | |
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MedLine Citation:
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PMID: 18495385 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Decabromodiphenyl ether (decaBDE) is a widely used brominated flame retardant, considered to be of low toxicity. However, previous toxicity studies applied exposure methods with low bioavailability of this compound, and the actual hazard of decaBDE for humans, which are environmentally exposed to decaBDE, may thus be underestimated in current risk assessments. The present 28 days oral toxicity study in Wistar rats was designed to facilitate detection of endocrine and immune modulating effects of decaBDE using an exposure protocol with improved bioavailability. A technical preparation of high purity decaBDE was thus tested by daily exposure through gavage with an emulsion of soy phospholipon/lutrol as a carrier. Most sensitive effect in males were increased weight of seminal vesicle/coagulation gland with BMDL of 0.2mg/kg bw/day and increased expression of hepatic CYP1A and CYP2B (BMDLs 0.5-0.7 mg/kg bw/day). In females the most sensitive effect was decreased activity of P450c17 (CYP17), which is a key enzyme in the androgen synthesis pathway, in adrenals (BMDL 0.18 mg/kg bw/day). These results suggest that decaBDE may represent an as yet unreported hazard for reproductive health. |
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Authors:
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Leo T M Van der Ven; Ton van de Kuil; Pim E G Leonards; Wout Slob; Rocío F Cantón; Silke Germer; Theo J Visser; Sabina Litens; Helen Håkansson; Dieter Schrenk; Martin van den Berg; Aldert H Piersma; Josephus G Vos; Antoon Opperhuizen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-03-12 |
Journal Detail:
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Title: Toxicology letters Volume: 179 ISSN: 0378-4274 ISO Abbreviation: Toxicol. Lett. Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-05-26 Completed Date: 2008-08-05 Revised Date: 2009-01-09 |
Medline Journal Info:
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Nlm Unique ID: 7709027 Medline TA: Toxicol Lett Country: Netherlands |
Other Details:
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Languages: eng Pagination: 6-14 Citation Subset: IM |
Affiliation:
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Laboratory for Health Protection Research, National Institute of Public Health and the Environment (RIVM), Bilthoven, The Netherlands. Leo.van.der.ven@rivm.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Animals Bone Density / drug effects Bone and Bones / drug effects, metabolism, radiography Cytochrome P-450 Enzyme System / metabolism Dose-Response Relationship, Drug Endocrine Glands / drug effects*, metabolism, pathology Female Flame Retardants / pharmacokinetics, toxicity* Halogenated Diphenyl Ethers Immune System / drug effects, pathology Liver / drug effects, enzymology Male Organ Size / drug effects Phenyl Ethers / pharmacokinetics, toxicity* Polybrominated Biphenyls / pharmacokinetics, toxicity* Prostate / drug effects, pathology Rats Rats, Wistar Reproduction / drug effects Risk Assessment Seminal Vesicles / drug effects, pathology Toxicity Tests |
| Chemical | |
Reg. No./Substance:
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0/Flame Retardants; 0/Halogenated Diphenyl Ethers; 0/Phenyl Ethers; 0/Polybrominated Biphenyls; 1163-19-5/decabromobiphenyl ether; 9035-51-2/Cytochrome P-450 Enzyme System |
| Comments/Corrections | |
Comment In:
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Toxicol Lett. 2008 Nov 10;182(1-3):127-9; author reply 130-2
[PMID:
18845229
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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