Document Detail


The 26 S proteasome is activated at two points in the ascidian cell cycle.
MedLine Citation:
PMID:  1397259     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The proteasome undergoes cell cycle-dependent changes in its subcellular distribution during ascidian embryonic development [(1992) Dev. Biol. 151, 27-33]. In this study, we demonstrate that the 26 S proteasome is markedly activated in both prophase and metaphase of the mitotic cell cycle in the ascidian embryos in comparison with the case of the 20 S proteasome. These results suggest that the 26 S proteasome is activated and participates in proteolysis at the restricted stages of the cell cycle.
Authors:
H Kawahara; H Sawada; H Yokosawa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  FEBS letters     Volume:  310     ISSN:  0014-5793     ISO Abbreviation:  FEBS Lett.     Publication Date:  1992 Sep 
Date Detail:
Created Date:  1992-11-04     Completed Date:  1992-11-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  119-22     Citation Subset:  IM    
Affiliation:
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blotting, Western
Cell Cycle*
Chromatography, Gel
Chymotrypsin / metabolism
Cysteine Endopeptidases / metabolism*
Enzyme Activation
Multienzyme Complexes / metabolism*
Proteasome Endopeptidase Complex
Urochordata / cytology,  enzymology*
Chemical
Reg. No./Substance:
0/Multienzyme Complexes; EC 3.4.21.1/Chymotrypsin; EC 3.4.22.-/Cysteine Endopeptidases; EC 3.4.25.1/Proteasome Endopeptidase Complex

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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