Document Detail

25(OH) vitamin D is associated with greater muscle strength in healthy men and women.
MedLine Citation:
PMID:  22895376     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The purpose of the study was to examine the relation between serum 25-hydroxy vitamin D (25(OH)D) levels and muscle strength in 419 healthy men and women over a broad age range (20-76 yr).
METHODS: Isometric and isokinetic strength of the arms and legs was measured using computerized dynamometry, and its relation to vitamin D was tested in multivariate models controlling for age, gender, resting HR, systolic blood pressure, diastolic blood pressure, body mass index, maximal oxygen uptake (VO(2max)), physical activity counts, and season of vitamin D measurement.
RESULTS: Vitamin D was significantly associated with arm and leg muscle strength when controlling for age and gender. When controlling for other covariates listed previously, vitamin D remained directly related to both isometric and isokinetic arm strength but only to isometric leg strength.
CONCLUSION: These data suggest that there may be a differential effect of vitamin D on upper and lower body strength. The mechanism for this difference remains unclear but could be related to differences in androgenic effects or to differences in vitamin D receptor expression. Our study supports a direct relation between vitamin D and muscle strength and suggests that vitamin D supplementation be evaluated to determine whether it is an effective therapy to preserve muscle strength in adults.
Adam S Grimaldi; Beth A Parker; Jeffrey A Capizzi; Priscilla M Clarkson; Linda S Pescatello; Michael C White; Paul D Thompson
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  45     ISSN:  1530-0315     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-18     Completed Date:  2013-05-17     Revised Date:  2014-01-10    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  157-62     Citation Subset:  IM; S    
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MeSH Terms
Biological Markers / blood
Cross-Sectional Studies
Isometric Contraction / physiology
Linear Models
Middle Aged
Multivariate Analysis
Muscle Strength / physiology*
Muscle Strength Dynamometer
Muscle, Skeletal / physiology*
Vitamin D / analogs & derivatives*,  blood
Grant Support
Reg. No./Substance:
0/Biological Markers; 1406-16-2/Vitamin D; 64719-49-9/25-hydroxyvitamin D

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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