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25-hydroxyvitamin D Concentrations in Patients with Optic Neuritis as a Clinically Isolated Syndrome and Healthy Controls.
MedLine Citation:
PMID:  22708027     Owner:  NLM     Status:  PubMed-not-MEDLINE    
OBJECTIVES: The onset of multiple sclerosis in the majority of the cases occurs as a clinically isolated syndrome (CIS). We sought to assess serum levels of 25-hydroxyvitamin D (25-OHD) in CIS patients and healthy controls.
METHODS: In this cross-sectional study 40 patients (36 women and 4 men) with CIS manifesting as a single isolated optic neuritis and 40 Age- and sex-matched healthy controls (35 women and 5 men) were enrolled between late October 2010 and early March 2011. General vitamin D deficiency was defined as serum 25-OHD levels of lower than 20 ng/ml and was classified as mild (15 < 25-OHD <20 ng/ml), moderate (8 < 25-OHD <15 ng/ml), and severe (25-OHD <8 ng/ml).
RESULTS: We found no difference in the median interquartile range [IQR] between CIS patients and controls (17.95 [10.40-29.13] vs. 17.00 [12.25-31.00]; P=0.57). However, when stratified by the levels of deficiency, among CIS patients a significantly higher proportion had severe vitamin D deficiency in comparison to healthy controls (20% vs. 2.5%; P=0.034). Nevertheless, the frequency of general (62.5% vs. 60%, P=0.82), mild (25% vs. 30%, P=0.80), and moderate (17.5% vs. 27.5%, P=0.42) vitamin D deficiency were not different between the two groups.
CONCLUSIONS: Our findings do not indicate any significant difference of serum 25-OHD between CIS patients and healthy controls. However, in our series severe vitamin D deficiency was more frequent among CIS patients.
Masoud Etemadifar; Seyed-Hossein Abtahi; Hassan Razmjoo; Mohammad-Ali Abtahi; Alireza Dehghani; Mehri Salari; Amir-Hadi Maghzi; Mojtaba Akbari
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of preventive medicine     Volume:  3     ISSN:  2008-8213     ISO Abbreviation:  Int J Prev Med     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-06-18     Completed Date:  2012-10-02     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  101535380     Medline TA:  Int J Prev Med     Country:  Iran    
Other Details:
Languages:  eng     Pagination:  313-7     Citation Subset:  -    
Isfahan Eye Research Center (IERC), Isfahan University of Medical Sciences, Isfahan, Iran.
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