Document Detail

25-hydroxycholecalciferol 1 alpha-hydroxylase activity in the kidney of the fetal, neonatal and adult guinea pig.
MedLine Citation:
PMID:  7388079     Owner:  NLM     Status:  MEDLINE    
Homogenates of fetal, newborn and maternal kidney and placenta have been compared with homogenates of non-pregnant adult kidney for their ability to hydroxylate 25-hydroxycholecalciferol. The activity in the fetal kidney near term is similar to that in the mother and 4--5 times that in the non-pregnant adult. These differences from the non-pregnant adult are significant (p less than 0.05 and 0.1 fetus and newborn, respectively). Even higher levels are present in some newborn 12--24 h after birth, but these values fall towards the non-pregnant level in the following 21 days. Significant hydroxylating activity is present in the near-term placenta.
E Fenton; H G Britton
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biology of the neonate     Volume:  37     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  1980  
Date Detail:
Created Date:  1980-09-26     Completed Date:  1980-09-26     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  254-6     Citation Subset:  IM    
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MeSH Terms
25-Hydroxyvitamin D3 1-alpha-Hydroxylase / metabolism*
Animals, Newborn
Guinea Pigs
Kidney / enzymology,  growth & development*
Steroid Hydroxylases / metabolism*
Reg. No./Substance:
EC 1.14.-/25-Hydroxyvitamin D3 1-alpha-Hydroxylase; EC 1.14.-/Steroid Hydroxylases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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