Document Detail


2',5'-Oligoadenylate and 2',5'-oligoadenylate phosphodiesterase in human plasma.
MedLine Citation:
PMID:  6517934     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
2',5'-Oligoadenylate and 2',5'-oligoadenylate phosphodiesterase activity were detected in the human plasma and serum by sensitive radioimmuno assays. The phosphodiesterase in the serum degraded 20 nM of added 2',5'-oligoadenylate in less than 1 hr. Addition of EDTA in the blood sample inhibited the phosphodiesterase activity completely and allowed the measurement of low levels of 2',5'-oligoadenylate. The concentration in the plasma from healty people was in the range of 0.03 to 0.3 nM.
Authors:
H Sawai; K Ishibashi; M Itoh; S Watanabe
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  125     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1984 Dec 
Date Detail:
Created Date:  1985-02-14     Completed Date:  1985-02-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1061-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
2',5'-Oligoadenylate Synthetase / blood*
Adenine Nucleotides / blood*
Humans
Microchemistry / methods
Oligonucleotides / blood*
Oligoribonucleotides / blood*
Radioimmunoassay
Reference Values
Chemical
Reg. No./Substance:
0/Adenine Nucleotides; 0/Oligonucleotides; 0/Oligoribonucleotides; 61172-40-5/2',5'-oligoadenylate; EC 2.7.7.-/2',5'-Oligoadenylate Synthetase

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