Document Detail

25-Hydroxycholecalciferol for early neonatal hypocalcemia. Occurrence in premature newborns.
MedLine Citation:
PMID:  717307     Owner:  NLM     Status:  MEDLINE    
Oral 25-hydroxycholecalciferol (25OHD3) has been used to prevent early neonatal hypocalcemia. Thirty premature neonates were studied prospectively from birth: 22 premature infants constituted a control group, and eight were treated orally with 25OHD3 (2 microgram/kg/day) for five days beginning within the first 12 hours of life. Eleven of the 22 premature infants in the control group became hypocalcemic, with serum ionized calcium (Ca++) level less than 3.0 mg/dl and total calcium (CaT) level less than 7.0 mg/dl on day 2 of life. Only one of the eight premature infants treated with 25OHD3 became hypocalcemic. In treated neonates, serum 25-hydroxyvitamin D, as well as serum Ca++ and CaT levels, increased during the first five days of life and were considerably greater than levels in control neonates. No untoward effects of this treatment were observed.
A R Fleischman; J F Rosen; G Nathenson
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of diseases of children (1960)     Volume:  132     ISSN:  0002-922X     ISO Abbreviation:  Am. J. Dis. Child.     Publication Date:  1978 Oct 
Date Detail:
Created Date:  1979-01-24     Completed Date:  1979-01-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370471     Medline TA:  Am J Dis Child     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  973-7     Citation Subset:  AIM; IM    
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MeSH Terms
Hydroxycholecalciferols / blood,  therapeutic use*
Hypocalcemia / epidemiology,  prevention & control*
Infant, Newborn
Infant, Premature, Diseases / epidemiology,  prevention & control*
Magnesium / blood
Phosphates / blood
Prospective Studies
Reg. No./Substance:
0/Hydroxycholecalciferols; 0/Phosphates; 7439-95-4/Magnesium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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