| 24S-hydroxycholesterol and cholesterol-24S-hydroxylase (CYP46A1) in the retina: from cholesterol homeostasis to pathophysiology of glaucoma. | |
| | |
MedLine Citation:
|
PMID: 21531213 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Free cholesterol is the predominant form of cholesterol in the neural retina. The vertebrate neural retina exhibits its own capacity to synthesize cholesterol and meets its demand also by taking it from the circulation. Defects in cholesterol synthesis and trafficking in the neural retina has detrimental consequences on its structure and function, highlighting the crucial importance of maintaining cholesterol homeostasis in the retina. Our purpose was to give a review on the functioning of the retina, the role of cholesterol and cholesterol metabolism therein, with special emphasis on cholesterol-24S-hydroxylase (CYP46A1). Similar to the brain, the retina expresses cholesterol-24S-hydroxylase (CYP46A1) and is enriched in its metabolic product, 24S-hydroxycholesterol. We recently published that one single nucleotide polymorphism in CYP46A1 gene, designated as rs754203, was a risk factor for glaucoma. Glaucoma is the second leading cause of blindness worldwide, affecting more than 60 million people. Glaucoma is characterized by the loss of retinal ganglion cells, which show high CYP46A1 expression. These data suggest the potential involvement of CYP46A1 and 24S-hydroxycholesterol in the pathophysiology of glaucoma. |
| | |
Authors:
|
Cynthia Fourgeux; Alain Bron; Niyazi Acar; Catherine Creuzot-Garcher; Lionel Bretillon |
Related Documents
:
|
8589783 - Cognitive effects of ketogenic weight-reducing diets. 11338073 - Bone mineral content and density in asymptomatic children with coeliac disease on a glu... 11041163 - Effects of imidapril on endothelin-1 and ace gene expression in failing hearts of salt-... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-4-21 |
Journal Detail:
|
Title: Chemistry and physics of lipids Volume: - ISSN: 1873-2941 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
|
Created Date: 2011-5-2 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0067206 Medline TA: Chem Phys Lipids Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011. Published by Elsevier Ireland Ltd. |
Affiliation:
|
Eye & Nutrition Research Group, Centre des Sciences du Goût et de l'Alimentation, UMR 1324 INRA, 6265 CNRS, University of Burgundy, Centre de recherche INRA, 17 rue Sully, F-21000 Dijon, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Phenotype-based drug screening in primary ovarian carcinoma cultures identifies intracellular iron d...
Next Document: Postprandial lipoprotein metabolism: VLDL vs chylomicrons.