Document Detail

24-hour systemic antibiotic prophylaxis in large-bowel surgery.
MedLine Citation:
PMID:  7015174     Owner:  NLM     Status:  MEDLINE    
In a prospective randomized double-blind trial the effect of a short prophylactic course of a systemically administered antibiotic combination was studied in a series of 53 consecutive patients undergoing elective colorectal surgery. Bowel preparation was performed conventionally with cathartics and saline enemas or with an elementary diet. Patients of both preparation groups were randomly divided into a treatment group and a control group. Treated patients received 3 doses of kanamycin 500 mg plus clindamycin 600 mg intramuscularly. Four patients were withdrawn from the study for various reasons, leaving 49 patients for analysis. Wound infections were regarded as slight (grade I) or clinically important (grade II). The frequency of all wound infections (grade I + grade II) was 8% in the treatment group (25 patients) versus 66.7% in the control group (24 patients). The frequency of the grade II wound infections alone was 4.0% versus 54.7%. The difference was significant in both cases (p less than 0.0005).
C Ulrich
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The Netherlands journal of surgery     Volume:  33     ISSN:  0167-2487     ISO Abbreviation:  Neth J Surg     Publication Date:  1981 Mar 
Date Detail:
Created Date:  1981-07-20     Completed Date:  1981-07-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8005043     Medline TA:  Neth J Surg     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  3-9     Citation Subset:  IM    
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MeSH Terms
Clindamycin / administration & dosage,  therapeutic use*
Clinical Trials as Topic
Injections, Intramuscular
Intestinal Diseases / surgery*
Intestinal Neoplasms / surgery
Intestine, Large / surgery*
Kanamycin / administration & dosage,  therapeutic use*
Middle Aged
Prospective Studies
Random Allocation
Surgical Wound Infection / prevention & control*
Time Factors
Reg. No./Substance:
18323-44-9/Clindamycin; 59-01-8/Kanamycin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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