| 24-hour systemic antibiotic prophylaxis in large-bowel surgery. | |
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MedLine Citation:
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PMID: 7015174 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In a prospective randomized double-blind trial the effect of a short prophylactic course of a systemically administered antibiotic combination was studied in a series of 53 consecutive patients undergoing elective colorectal surgery. Bowel preparation was performed conventionally with cathartics and saline enemas or with an elementary diet. Patients of both preparation groups were randomly divided into a treatment group and a control group. Treated patients received 3 doses of kanamycin 500 mg plus clindamycin 600 mg intramuscularly. Four patients were withdrawn from the study for various reasons, leaving 49 patients for analysis. Wound infections were regarded as slight (grade I) or clinically important (grade II). The frequency of all wound infections (grade I + grade II) was 8% in the treatment group (25 patients) versus 66.7% in the control group (24 patients). The frequency of the grade II wound infections alone was 4.0% versus 54.7%. The difference was significant in both cases (p less than 0.0005). |
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Authors:
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C Ulrich |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: The Netherlands journal of surgery Volume: 33 ISSN: 0167-2487 ISO Abbreviation: Neth J Surg Publication Date: 1981 Mar |
Date Detail:
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Created Date: 1981-07-20 Completed Date: 1981-07-20 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8005043 Medline TA: Neth J Surg Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 3-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Clindamycin / administration & dosage, therapeutic use* Clinical Trials as Topic Female Humans Injections, Intramuscular Intestinal Diseases / surgery* Intestinal Neoplasms / surgery Intestine, Large / surgery* Kanamycin / administration & dosage, therapeutic use* Male Middle Aged Prospective Studies Random Allocation Surgical Wound Infection / prevention & control* Time Factors |
| Chemical | |
Reg. No./Substance:
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18323-44-9/Clindamycin; 59-01-8/Kanamycin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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