Document Detail

24-hour pH monitoring in symptomatic patients without erosive esophagitis who did not respond to antireflux treatment.
MedLine Citation:
PMID:  7963375     Owner:  NLM     Status:  MEDLINE    
Twenty symptomatic patients without erosive esophagitis underwent 24-h esophageal pH monitoring after failing standard medical antireflux treatment. Sixty-five percent had abnormal esophageal acid exposure, and the majority of these improved on proton pump inhibitor therapy. However, 35% had a normal 24-h pH test. One patient had coronary artery disease, one had diffuse esophageal spasm, and two had a negative work-up and no improvement with omeprazole. Consequently, we suggest that patients like these have an omeprazole trial. If symptoms persist, 24-h esophageal pH monitoring can appropriately define more rational management. Patients with abnormal esophageal acid exposure will require more aggressive acid-control therapy, whereas those with normal esophageal acid exposure will need further work-up to assess the cause of their symptoms.
R Fass; C Mackel; R E Sampliner
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical gastroenterology     Volume:  19     ISSN:  0192-0790     ISO Abbreviation:  J. Clin. Gastroenterol.     Publication Date:  1994 Sep 
Date Detail:
Created Date:  1994-12-28     Completed Date:  1994-12-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7910017     Medline TA:  J Clin Gastroenterol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  97-9     Citation Subset:  IM    
University of Arizona Health Sciences Center, Tucson.
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MeSH Terms
Aged, 80 and over
Anti-Ulcer Agents / therapeutic use
Esophagus / secretion
Gastroesophageal Reflux / drug therapy,  physiopathology*
Hydrogen-Ion Concentration
Middle Aged
Monitoring, Ambulatory*
Omeprazole / therapeutic use
Prospective Studies
Proton Pumps / antagonists & inhibitors
Treatment Failure
Reg. No./Substance:
0/Anti-Ulcer Agents; 0/Proton Pumps; 73590-58-6/Omeprazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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