Document Detail

24-hour ambulatory blood pressure monitoring in children with familial dysautonomia.
MedLine Citation:
PMID:  15714311     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Familial dysautonomia (Riley Day syndrome) is a genetic disease. The present study of 24-hour ambulatory blood pressure monitoring in children with familial dysautonomia was carried out to investigate the pattern of blood pressure in this syndrome. OBJECTIVE: To the best of our knowledge, this is the only description of patients with 24-hour blood pressure monitoring. STUDY DESIGN: Vasomotor instability reflected in extreme hypertension and hypotension was recorded by 24-hour ambulatory blood pressure monitoring in three patients with familial dysautonomia: a 16-year old girl, a 14-year old boy and a 3-year old boy. Recordings were taken on a routine school day in the first two patients and during hospitalization in the third. RESULTS: Patients 1 and 2 displayed circadian rhythm but with significantly higher than normal blood pressure and heart rate. Patient 3 exhibited these fluctuations to a lesser degree. Postural hypotension without compensatory tachycardia was frequently seen in all three patients. Unusual variability in blood pressure was recorded during routine activities in patients 1 and 2 and during an acute attack in patient 3. CONCLUSIONS: Close monitoring of antihypertensive therapy should be considered in familial dysautonomia patients in whom blood pressure reaches excessive levels.
Naomi Nussinovitch; Moshe Nussinovitch; Edna Peleg; Talma Rosenthal
Publication Detail:
Type:  Journal Article     Date:  2005-02-16
Journal Detail:
Title:  Pediatric nephrology (Berlin, Germany)     Volume:  20     ISSN:  0931-041X     ISO Abbreviation:  Pediatr. Nephrol.     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-03-04     Completed Date:  2005-06-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8708728     Medline TA:  Pediatr Nephrol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  507-11     Citation Subset:  IM    
A.J. Chorley Institute for Hypertension, Chaim Sheba Medical Center, Tel Hashomer, Israel.
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MeSH Terms
Blood Pressure Monitoring, Ambulatory*
Case-Control Studies
Child, Preschool
Circadian Rhythm*
Dysautonomia, Familial / complications*,  physiopathology
Heart Rate
Hypertension / diagnosis*,  etiology
Hypotension / diagnosis*,  etiology
Hypotension, Orthostatic / diagnosis,  etiology

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