Document Detail

24-hour Holter-monitoring in the perianaesthetic period in dogs premedicated with dexmedetomidine.
MedLine Citation:
PMID:  12505396     Owner:  NLM     Status:  MEDLINE    
Baseline and perianaesthetic 24-hour Holter recordings were carried out in six healthy beagles. After dexmedetomidine premedication anaesthesia was induced with propofol and maintained with propofol infusion or isoflurane for one hour. Dexmedetomidine alone was used as control. The recordings were analysed for ventricular premature complexes (VPC), atrioventricular (AV) blocks and mean heart rate/hour (HR). In most recordings, no ventricular arrhythmias were detected, the maximum frequency being two VPCs/24 h. VPCs were not seen during anaesthesia or during the recovery period. The development of second-degree AV-blocks varied from dog to dog. Most of the heart blocks were seen during the premedication period when bradycardia was most prominent. During the subsequent night, HR was similar between treatments and did not differ from that seen on the baseline recordings. In beagles treated with dexmedetomidine alone or combined with propofol or propofol/isoflurane, ventricular arrhythmias were not detected more frequently than those reported in healthy non-anaesthetised dogs.
E Kuusela; M Raekallio; H Hietanen; J Huttula; O Vainio
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Veterinary journal (London, England : 1997)     Volume:  164     ISSN:  1090-0233     ISO Abbreviation:  Vet. J.     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-12-30     Completed Date:  2003-05-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9706281     Medline TA:  Vet J     Country:  England    
Other Details:
Languages:  eng     Pagination:  235-9     Citation Subset:  IM    
Copyright Information:
Copyright 2002 Published by Elsevier Science Ltd.
Faculty of Veterinary Medicine, Department of Clinical Veterinary Sciences, Helsinki University, PO Box 57, FIN-00014, Helsinki, Finland.
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MeSH Terms
Anesthesia, General / veterinary
Anesthetics, Inhalation / adverse effects
Anesthetics, Intravenous / adverse effects
Arrhythmias, Cardiac / chemically induced*
Dexmedetomidine / administration & dosage,  adverse effects*
Drug Interactions
Drug Monitoring*
Heart Rate / drug effects*
Hypnotics and Sedatives / administration & dosage,  adverse effects
Isoflurane / administration & dosage,  adverse effects
Preanesthetic Medication / adverse effects*,  veterinary*
Propofol / administration & dosage,  adverse effects
Time Factors
Reg. No./Substance:
0/Anesthetics, Inhalation; 0/Anesthetics, Intravenous; 0/Hypnotics and Sedatives; 113775-47-6/Dexmedetomidine; 2078-54-8/Propofol; 26675-46-7/Isoflurane

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