Document Detail

24 h rhythm of blood pressure and forearm peripheral resistance in normotensive and hypertensive subjects confined to bed.
MedLine Citation:
PMID:  12013494     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To define whether a diurnal rhythm of peripheral resistance exists in normotensive and hypertensive subjects, has any relationship with that of blood pressure and differs in dipper and non-dipper hypertensives. DESIGN AND METHODS: Forty-three subjects (13 normotensives and 30 mild-to-moderate essential hypertensives) confined for 24 h to bed were included. Blood pressure was recorded for 22 h at 15 min intervals, plethysmographic forearm flow was simultaneously measured and forearm resistance calculated. The analysis was performed for the whole 22 h period and for three 4 h truncated periods, two of certain wakefulness and one of certain sleep. RESULTS: A circadian rhythm of forearm resistance was shown in the normotensives, paralleling that of blood pressure. All the normotensives were dippers, with a nocturnal blood pressure dip (systolic/diastolic) of -4.5/-6.0%. In the hypertensives, the day/night blood pressure trends were not homogeneous: 21 showed higher blood pressure values during waking time, with a trend quite similar to that of the normotensives, whereas the other nine were non-dippers. Resistance was lower during sleep than during waking both in the normotensives and in the dipper hypertensives, whereas in the non-dippers it was higher during sleep. CONCLUSIONS: A sleep/waking rhythm of peripheral resistance with the highest values during daytime and the lowest during night-time does exist in normotensive as well as in the majority of hypertensive subjects resting continuously in bed, and therefore is largely independent of physical activity. Only in a minority of hypertensive patients are higher values of peripheral resistance present during sleep.
E Casiglia; P Palatini; G Colangeli; G Ginocchio; G Di Menza; C Onesto; L Pegoraro; R Biasin; C Canali; A C Pessina
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of hypertension     Volume:  14     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  1996 Jan 
Date Detail:
Created Date:  2002-05-15     Completed Date:  2002-06-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  47-52     Citation Subset:  IM    
Department of Clinical and Experimental Medicine, University of Padova, Italy.
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MeSH Terms
Age Factors
Blood Pressure / physiology*
Body Mass Index
Circadian Rhythm / physiology*
Forearm / blood supply*
Heart Rate / physiology
Hypertension / physiopathology*
Middle Aged
Reference Values
Sex Factors
Vascular Resistance / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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