Document Detail

2,4-Dichlorophenoxyacetic acid effects on polyamine biosynthesis.
MedLine Citation:
PMID:  1891779     Owner:  NLM     Status:  MEDLINE    
2,4-Dichlorophenoxyacetic acid (2,4-D) is a herbicide extensively used in agriculture. It was considered of interest to study its toxicity on animal cells. We had previously determined that 1 mM 2,4-D can inhibit cell growth, DNA and protein synthesis of cultured Chinese hamster ovary cells (CHO) with cell accumulation in the G1/S interphase of the cell cycle. The present work examined the effects of 2,4-D on polyamine biosynthesis. The results suggest some possible mechanism of the herbicide's toxic effects on animal cells.
V Rivarola; H Balegno
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Toxicology     Volume:  68     ISSN:  0300-483X     ISO Abbreviation:  Toxicology     Publication Date:  1991  
Date Detail:
Created Date:  1991-10-16     Completed Date:  1991-10-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0361055     Medline TA:  Toxicology     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  109-19     Citation Subset:  IM    
Departamento Biología Molecular, Facultad de Ciencias Exactas, Físico-Químicas y Naturales, Universidad Nacional de Río Cuarto, Córdoba, Argentina.
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MeSH Terms
2,4-Dichlorophenoxyacetic Acid / toxicity*
Cell Division / drug effects
Cell Line
Culture Media
DNA / biosynthesis,  drug effects
Ornithine Decarboxylase / analysis
Polyamines / metabolism*
Protein Biosynthesis
Proteins / drug effects
Putrescine / biosynthesis,  pharmacology
Spermidine / biosynthesis,  pharmacology
Spermidine Synthase / analysis
Spermine / biosynthesis,  pharmacology
Spermine Synthase / analysis
Reg. No./Substance:
0/Culture Media; 0/Polyamines; 0/Proteins; 110-60-1/Putrescine; 124-20-9/Spermidine; 71-44-3/Spermine; 9007-49-2/DNA; 94-75-7/2,4-Dichlorophenoxyacetic Acid; EC Synthase; EC Synthase; EC Decarboxylase

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