| 23Na Magnetic Resonance Imaging of Tissue Sodium. | |
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MedLine Citation:
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PMID: 22146510 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Hypertension is linked to disturbed total-body sodium (Na(+)) regulation; however, measuring Na(+) disposition in the body is difficult. We implemented (23)Na magnetic resonance spectroscopy ((23)Na-MR) and imaging technique ((23)Na-MRI) at 9.4T for animals and 3T for humans to quantify Na(+) content in skeletal muscle and skin. We compared (23)Na-MRI data with actual tissue Na(+) content measured by chemical analysis in animal and human tissue. We then quantified tissue Na(+) content in normal humans and in patients with primary aldosteronism. We found a 29% increase in muscle Na(+) content in patients with aldosteronism compared with normal women and men. This tissue Na(+) was mobilized after successful treatment without accompanying weight loss. We suggest that, after further refinements, this tool could facilitate understanding the relationships between Na(+) accumulation and hypertension. Furthermore, with additional technical advances, a future clinical use may be possible. |
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Authors:
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Christoph Kopp; Peter Linz; Lydia Wachsmuth; Anke Dahlmann; Thomas Horbach; Christof Schöfl; Wolfgang Renz; Davide Santoro; Thoralf Niendorf; Dominik N Müller; Myriam Neininger; Alexander Cavallaro; Kai-Uwe Eckardt; Roland E Schmieder; Friedrich C Luft; Michael Uder; Jens Titze |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-5 |
Journal Detail:
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Title: Hypertension Volume: - ISSN: 1524-4563 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7906255 Medline TA: Hypertension Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Nephrology and Hypertension, Interdisciplinary Center for Clinical Research, Nikolaus-Fiebiger-Center for Molecular Medicine, Division of Endocrinology and Diabetes, Department of Medicine I, Department of Experimental Medicine I, Nikolaus-Fiebiger-Center for Molecular Medicine, and Department of Radiology, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany; Research Group for Experimental Magnetic Resonance, Westfälische-Wilhelms-University Münster, Germany; Department of Surgery, Hospital Schwabach, Schwabach, Germany; Siemens Healthcare, Erlangen, Germany; Berlin Ultrahigh-Field Facility and the Experimental and Clinical Research Center, Charité Medical Faculty and Max-Delbrück Center for Molecular Medicine, Berlin, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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