| 23Na MR imaging at 7 T after knee matrix-associated autologous chondrocyte transplantation preliminary results. | |
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MedLine Citation:
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PMID: 20713608 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To evaluate the feasibility of sodium 7-T magnetic resonance (MR) imaging in repaired tissue and native cartilage of patients after matrix-associated autologous chondrocyte transplantation (MACT) and compare results with delayed gadolinium-enhanced MR imaging of cartilage (dGEMRIC) at 3 T. MATERIALS AND METHODS: Ethical approval was provided by the local ethics committee; written informed consent was obtained from all patients. Six women and six men (mean age, 32.8 year ± 8.2 [standard deviation] and 32.3 years ± 12.7, respectively) were included. Mean time between MACT and MR was 56 months ± 28. A variable three-dimensional (3D) gradient-echo (GRE) dual-flip-angle technique was used for T1 mapping before and after contrast agent administration at 3 T. All patients were also examined at 7 T (mean delay, 70.5 days ± 80.1). A sodium 23-only transmit-receive knee coil was used with the 3D GRE sequence. A statistical analysis of variance and Pearson correlation were applied. RESULTS: Mean signal-to-noise ratio (SNR) was 24 in native cartilage and was 16 in transplants (P < .001). Mean sodium signal intensities normalized with the reference sample were 174 ± 53 and 267 ± 42 for repaired tissue in the cartilage transplant and healthy cartilage, respectively (P < .001). Mean postcontrast T1 values were 510 msec ± 195 and 756 msec ± 188 for repaired tissue and healthy cartilage, respectively (P = .005). Mean score of MR observation of cartilage repair tissue was 75 ± 14. Association between postcontrast T1 and normalized sodium signal values showed a high Pearson correlation coefficient (R) of 0.706 (P = .001). A high correlation of R = 0.836 (P = .001) was found between ratios of normalized sodium values and ratios of T1 postcontrast values. CONCLUSION: With the modified 3D GRE sequence at 7 T, a sufficiently high SNR in sodium images was achieved, allowing for differentiation of repaired tissue from native cartilage after MACT. A strong correlation was found between sodium imaging and dGEMRIC in patients after MACT. |
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Authors:
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Siegfried Trattnig; Goetz H Welsch; Vladimir Juras; Pavol Szomolanyi; Marius E Mayerhoefer; David Stelzeneder; Tallal C Mamisch; Oliver Bieri; Klaus Scheffler; Stefan Zbýn |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-08-16 |
Journal Detail:
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Title: Radiology Volume: 257 ISSN: 1527-1315 ISO Abbreviation: Radiology Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-20 Completed Date: 2010-10-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401260 Medline TA: Radiology Country: United States |
Other Details:
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Languages: eng Pagination: 175-84 Citation Subset: AIM; IM |
Affiliation:
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Department of Radiology, MR Centre-High Field MR, Medical University of Vienna, Lazarettgasse 14, Vienna, Austria. siegfried.trattnig@meduniwien.ac.at |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Analysis of Variance Cartilage, Articular / pathology*, surgery* Chondrocytes / transplantation* Contrast Media Feasibility Studies Female Humans Imaging, Three-Dimensional Knee Joint / pathology*, surgery* Magnetic Resonance Imaging / methods* Male Sodium Isotopes / diagnostic use Transplantation, Autologous Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/Sodium Isotopes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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