| 2,3,7,8-Tetrachlorodibenzo-p-dioxin in maternal breast milk and newborn head circumference. | |
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MedLine Citation:
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PMID: 17551544 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dioxins are known to affect infant growth and neurodevelopment in both humans and animals. In this study, we examined the relationship between neonatal head circumference, which is related to fetal brain development, and the concentration of dioxins in breast milk as an indicator of maternal exposure. A total of 42 milk samples were obtained on the fifth to eighth postpartum day from mothers in Japan exposed to dioxins in the environment. The levels of seven dioxins and 10 furan isomers were measured in each milk sample using an HR-GC/MS system. The relationships between the concentration of each dioxin isomer and newborn size, including head circumference, were then investigated after adjustment for confounding factors. The concentration of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), the most toxic dioxin isomer, negatively correlated with newborn head circumference, even after adjustment for gestational age, infant sex, parity and other confounding factors. However, there were no significant relationships between the concentration of other dioxin and furan isomers in maternal breast milk and infant height, weight and chest circumference at birth. These facts suggested that fetal brain development might be influenced by maternal exposure to TCDD in the environment. |
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Authors:
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Muneko Nishijo; Kenji Tawara; Hideaki Nakagawa; Ryumon Honda; Teruhiko Kido; Hisao Nishijo; Shigeru Saito |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-06-06 |
Journal Detail:
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Title: Journal of exposure science & environmental epidemiology Volume: 18 ISSN: 1559-064X ISO Abbreviation: - Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-04-18 Completed Date: 2008-06-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101262796 Medline TA: J Expo Sci Environ Epidemiol Country: United States |
Other Details:
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Languages: eng Pagination: 246-51 Citation Subset: IM |
Affiliation:
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Department of Public Health, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Ishikawa 920-0293, Japan. ni-koei@kanazawa-med.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Body Weights and Measures
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methods Brain / anatomy & histology*, growth & development Breast Feeding Cephalometry / methods Environmental Pollutants / toxicity* Female Furans / toxicity Gestational Age Head / anatomy & histology*, growth & development Humans Infant Infant, Newborn Japan Maternal Exposure / adverse effects* Milk, Human / chemistry* Pregnancy Risk Assessment Tetrachlorodibenzodioxin / toxicity* Thorax / anatomy & histology, growth & development |
| Chemical | |
Reg. No./Substance:
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0/Environmental Pollutants; 0/Furans; 1746-01-6/Tetrachlorodibenzodioxin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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