Document Detail

2,3,7,8-Tetrachlorodibenzo-p-dioxin in maternal breast milk and newborn head circumference.
MedLine Citation:
PMID:  17551544     Owner:  NLM     Status:  MEDLINE    
Dioxins are known to affect infant growth and neurodevelopment in both humans and animals. In this study, we examined the relationship between neonatal head circumference, which is related to fetal brain development, and the concentration of dioxins in breast milk as an indicator of maternal exposure. A total of 42 milk samples were obtained on the fifth to eighth postpartum day from mothers in Japan exposed to dioxins in the environment. The levels of seven dioxins and 10 furan isomers were measured in each milk sample using an HR-GC/MS system. The relationships between the concentration of each dioxin isomer and newborn size, including head circumference, were then investigated after adjustment for confounding factors. The concentration of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), the most toxic dioxin isomer, negatively correlated with newborn head circumference, even after adjustment for gestational age, infant sex, parity and other confounding factors. However, there were no significant relationships between the concentration of other dioxin and furan isomers in maternal breast milk and infant height, weight and chest circumference at birth. These facts suggested that fetal brain development might be influenced by maternal exposure to TCDD in the environment.
Muneko Nishijo; Kenji Tawara; Hideaki Nakagawa; Ryumon Honda; Teruhiko Kido; Hisao Nishijo; Shigeru Saito
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-06-06
Journal Detail:
Title:  Journal of exposure science & environmental epidemiology     Volume:  18     ISSN:  1559-064X     ISO Abbreviation:  -     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-04-18     Completed Date:  2008-06-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101262796     Medline TA:  J Expo Sci Environ Epidemiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  246-51     Citation Subset:  IM    
Department of Public Health, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Ishikawa 920-0293, Japan.
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MeSH Terms
Body Weights and Measures / methods
Brain / anatomy & histology*,  growth & development
Breast Feeding
Cephalometry / methods
Environmental Pollutants / toxicity*
Furans / toxicity
Gestational Age
Head / anatomy & histology*,  growth & development
Infant, Newborn
Maternal Exposure / adverse effects*
Milk, Human / chemistry*
Risk Assessment
Tetrachlorodibenzodioxin / toxicity*
Thorax / anatomy & histology,  growth & development
Reg. No./Substance:
0/Environmental Pollutants; 0/Furans; 1746-01-6/Tetrachlorodibenzodioxin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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