Document Detail

2308 second trimester terminations using extra-amniotic or intra-amniotic prostaglandin E2: an analysis of efficacy and complications.
MedLine Citation:
PMID:  2620054     Owner:  NLM     Status:  MEDLINE    
A total of 2308 mid-trimester terminations using PGE2 extra-amniotically (1608) or intra-amniotically (700) has been analysed for efficacy and immediate and early morbidity. The mean induction-to-abortion intervals were similar for the two routes. Overall, 67% of the patients were in hospital for 1 night. Morbidity rates were similar for the two administration routes and were no higher than those reported for second trimester terminations using dilatation and evacuation. Minor side-effects of vomiting occurred in 1006 (44%) and diarrhoea in 320 (14%). Forty (1.7%) lost more than 500 ml of blood during termination and 13 (0.6%) were transfused. Major complications were extremely rare and genital tract trauma only occurred in 4 (0.17%) and proven pelvic infection in 2 (0.08%) patients. Thirty-three (1.4%) were readmitted and required a surgical evacuation of the uterus. Since long-term complications have been assessed for this method of termination and found to be infrequent, we see no reason to consider a change in methods for second trimester terminations.
N C Hill; I Z MacKenzie
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of obstetrics and gynaecology     Volume:  96     ISSN:  0306-5456     ISO Abbreviation:  Br J Obstet Gynaecol     Publication Date:  1989 Dec 
Date Detail:
Created Date:  1990-03-21     Completed Date:  1990-03-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7503752     Medline TA:  Br J Obstet Gynaecol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1424-31     Citation Subset:  AIM; IM; J    
Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital.
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MeSH Terms
Abortion, Induced*
Dinoprostone / administration & dosage*,  adverse effects
Dose-Response Relationship, Drug
Fever / etiology
Genitalia, Female / injuries
Infection / etiology
Length of Stay
Patient Readmission
Postpartum Hemorrhage / etiology
Pregnancy Trimester, Second
Time Factors
Vomiting / etiology
Reg. No./Substance:

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