Document Detail


23-Hydroxybetulinic acid from Pulsatilla chinensis (Bunge) Regel synergizes the antitumor activities of doxorubicin in vitro and in vivo.
MedLine Citation:
PMID:  20176097     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM OF THIS STUDY: To evaluate the combinational anticancer effect of 23-hydroxybetulinic acid and doxorubicin in vitro and in vivo.
MATERIALS AND METHODS: The effect of combination treatment with 23-hydroxybetulinic acid and doxorubicin was evaluated with a quantitative combination index method based on the median-effect analysis in various cancer cell lines. And in vivo efficacy of combination chemotherapy was also evaluated using ICR mice bearing sarcoma 180 carcinoma tumors.
RESULTS: 23-Hydroxybetulinic acid showed a synergistic cytotoxic effect on multiple cancer cell lines by combined use with doxorubicin. In vivo studies further demonstrated that co-administration of 23-HBA significantly improved the sensitivity of the tumor to doxorubicin through increasing intra-tumor doxorubicin concentration and inhibiting doxorubicin-induced up-regulation of P-gp in tumor.
CONCLUSION: These results suggest that the combined therapy with 23-hydroxybetulinic acid and doxorubicin may be a new promising strategy to promote the clinical chemotherapy, which needs further verification.
Authors:
Yuanting Zheng; Fang Zhou; Xiaolan Wu; Xiaozhou Wen; Yannan Li; Bei Yan; Jingwei Zhang; Gang Hao; Wencai Ye; Guangji Wang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-02-20
Journal Detail:
Title:  Journal of ethnopharmacology     Volume:  128     ISSN:  1872-7573     ISO Abbreviation:  J Ethnopharmacol     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-12     Completed Date:  2010-07-13     Revised Date:  2011-01-11    
Medline Journal Info:
Nlm Unique ID:  7903310     Medline TA:  J Ethnopharmacol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  615-22     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, Jiangsu, China.
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MeSH Terms
Descriptor/Qualifier:
Animals
Doxorubicin / administration & dosage,  pharmacology*,  therapeutic use*
Humans
Male
Mice
Mice, Inbred ICR
P-Glycoprotein / pharmacology
Pulsatilla / chemistry*
Triterpenes
Up-Regulation / drug effects
Chemical
Reg. No./Substance:
0/23-hydroxybetulinic acid; 0/P-Glycoprotein; 0/Triterpenes; 23214-92-8/Doxorubicin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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