| 2,3-dibenzylbutyrolactones and 1,2,3,4-tetrahydro-2-naphthoic acid gamma-lactones: structure and activity relationship in cytotoxic activity. | |
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MedLine Citation:
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PMID: 12135092 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dibenzyl-g-butyrolactone and 1,2,3,4-tetrahydro-2-naphthoic acid gamma-lactone (TNL) derivatives were synthesized and evaluated for cytotoxic activity against some cancer cell lines. It was found that TNL derivatives with a shorter distance between C-4 in ring A and C'-2 in ring C were more cytotoxic, while dibenzyl-gamma-butyrolactones with a longer one were nearly inactive. In TNL series, presence of 3,4-dioxy group in ring A and 2-methoxy group in ring C was essential for the enhancement of the activity. |
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Authors:
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Yong Kim; Young-Jae You; Nguyen-Hai Nam; Byung-Zun Ahn |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Archives of pharmacal research Volume: 25 ISSN: 0253-6269 ISO Abbreviation: Arch. Pharm. Res. Publication Date: 2002 Jun |
Date Detail:
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Created Date: 2002-07-23 Completed Date: 2003-01-07 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8000036 Medline TA: Arch Pharm Res Country: Korea (South) |
Other Details:
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Languages: eng Pagination: 240-9 Citation Subset: IM |
Affiliation:
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College of Pharmacy, Chungnam National University, Daejeon, Korea. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents
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chemical synthesis*,
chemistry,
pharmacology Drug Screening Assays, Antitumor Humans Indicators and Reagents Lactones / chemical synthesis*, chemistry, pharmacology Magnetic Resonance Spectroscopy Naphthalenes / chemical synthesis*, chemistry, pharmacology Spectrophotometry, Infrared Spectroscopy, Fourier Transform Infrared Structure-Activity Relationship Tumor Cells, Cultured |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Indicators and Reagents; 0/Lactones; 0/Naphthalenes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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