Document Detail


23-Hydroxybetulinic acid-mediated apoptosis is accompanied by decreases in bcl-2 expression and telomerase activity in HL-60 Cells.
MedLine Citation:
PMID:  12409140     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
23-Hydroxybetulinic acid, a derivative of betulinic acid, was investigated for its apoptotic effect and the associated telomerase activity in human leukemia HL-60 cells. Apoptosis and bcl-2 were determined by flow cytometry analysis. A PCR-based telomeric repeat amplification protocol assay was used to detect telomerase activity. Results showed that 23-hydroxybetulinic acid induced growth arrest and apoptotic cell death in HL-60 cells. The apoptotic events were associated with concurrent down-regulation of bcl-2 and the telomerase activity. Our data suggest that 23-hydroxybetulinic acid may be a potential cytotoxic agent for treatment of cancer.
Authors:
Zhao-Ning Ji; Wen-Cai Ye; Guo-Ging Liu; W L Wendy Hsiao
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Life sciences     Volume:  72     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-10-31     Completed Date:  2002-12-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  1-9     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, China Pharmaceutical University, 210009, Nanjing, China
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents, Phytogenic / chemistry,  toxicity*
Apoptosis*
Cell Division / drug effects
Flow Cytometry
Fluorescent Antibody Technique
HL-60 Cells
Humans
Proto-Oncogene Proteins c-bcl-2 / immunology,  metabolism*
Telomerase / metabolism*
Triterpenes / chemistry,  toxicity*
Chemical
Reg. No./Substance:
0/23-hydroxybetulinic acid; 0/Antineoplastic Agents, Phytogenic; 0/Proto-Oncogene Proteins c-bcl-2; 0/Triterpenes; EC 2.7.7.49/Telomerase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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