Document Detail


21st century natural product research and drug development and traditional medicines.
MedLine Citation:
PMID:  23450245     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Natural products and related structures are essential sources of new pharmaceuticals, because of the immense variety of functionally relevant secondary metabolites of microbial and plant species. Furthermore, the development of powerful analytical tools based upon genomics, proteomics, metabolomics, bioinformatics and other 21st century technologies are greatly expediting identification and characterization of these natural products. Here we discuss the synergistic and reciprocal benefits of linking these 'omics technologies with robust ethnobotanical and ethnomedical studies of traditional medicines, to provide critically needed improved medicines and treatments that are inexpensive, accessible, safe and reliable. However, careless application of modern technologies can challenge traditional knowledge and biodiversity that are the foundation of traditional medicines. To address such challenges while fulfilling the need for improved (and new) medicines, we encourage the development of Regional Centres of 'omics Technologies functionally linked with Regional Centres of Genetic Resources, especially in regions of the world where use of traditional medicines is prevalent and essential for health.
Authors:
Linh T Ngo; Joseph I Okogun; William R Folk
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Publication Detail:
Type:  Historical Article; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Natural product reports     Volume:  30     ISSN:  1460-4752     ISO Abbreviation:  Nat Prod Rep     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-13     Completed Date:  2013-05-09     Revised Date:  2014-04-15    
Medline Journal Info:
Nlm Unique ID:  8502408     Medline TA:  Nat Prod Rep     Country:  England    
Other Details:
Languages:  eng     Pagination:  584-92     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Antimalarials / chemistry,  pharmacology
Antitubercular Agents / chemistry,  pharmacology
Biological Products* / chemistry,  isolation & purification,  pharmacology
Drug Discovery
History, 21st Century
Medicine, Traditional
Molecular Structure
Plant Preparations / pharmacology
Plants, Medicinal / chemistry*
Grant Support
ID/Acronym/Agency:
3U19AT003264/AT/NCCAM NIH HHS; P50 AT006273/AT/NCCAM NIH HHS; P50AT006273/AT/NCCAM NIH HHS
Chemical
Reg. No./Substance:
0/Antimalarials; 0/Antitubercular Agents; 0/Biological Products; 0/Plant Preparations
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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