Document Detail


211 G to a variation of UDP-glucuronosyl transferase 1A1 gene and neonatal breastfeeding jaundice.
MedLine Citation:
PMID:  20975617     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Breastfeeding jaundice is a common problem in neonates who were exclusively breastfed, but its pathogenesis is still unclear. The uridine diphosphate glucuronosyl transferase 1A1 (UGT1A1) gene polymorphism was shown to contribute to the development of neonatal hyperbilirubinemia. We hypothesize that the variation of UGT1A1 gene may contribute to neonatal breastfeeding jaundice. We prospectively enrolled 688 near-term and term infants who were exclusively breastfed (BF group) or were supplemented by infant formula partially (SF group) before onset of hyperbilirubinemia. Genotyping of the promoter and exon1 of UGT1A1 was performed in all neonates. Neonates in BF group had a significantly higher maximal body weight loss ratio, peak bilirubin level, and a greater incidence of hyperbilirubinemia than those in SF group. Neonates with nucleotide 211 GA or AA variation in UGT1A1 genotypes had higher peak serum bilirubin levels and higher incidence of hyperbilirubinemia than WTs (GG). This phenomenon was only seen in BF group but not in SF group when subset analysis was performed. This suggests that neonates who carry the nucleotide 211 GA or AA variation within coding region in UGT1A1 gene are more susceptible to develop early-onset neonatal breastfeeding jaundice.
Authors:
Hung-Chieh Chou; Mei-Huei Chen; Hwai-I Yang; Yi-Ning Su; Wu-Shiun Hsieh; Chien-Yi Chen; Huey-Ling Chen; Mei-Hwei Chang; Po-Nien Tsao
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric research     Volume:  69     ISSN:  1530-0447     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-12     Completed Date:  2011-05-09     Revised Date:  2014-03-28    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  170-4     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Bilirubin / blood
Bottle Feeding
Breast Feeding / adverse effects*
Chi-Square Distribution
Exons
Female
Genetic Predisposition to Disease
Glucuronosyltransferase / genetics*
Humans
Hyperbilirubinemia, Neonatal / blood,  enzymology,  genetics*
Infant Formula
Infant, Newborn
Jaundice, Neonatal / blood,  enzymology,  genetics*
Linear Models
Logistic Models
Male
Odds Ratio
Phenotype
Polymorphism, Genetic*
Promoter Regions, Genetic
Prospective Studies
Risk Assessment
Risk Factors
Chemical
Reg. No./Substance:
EC 2.4.1.-/UGT1A1 enzyme; EC 2.4.1.17/Glucuronosyltransferase; RFM9X3LJ49/Bilirubin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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