Document Detail


20q- clonality in a case of oral sweet syndrome and myelodysplasia.
MedLine Citation:
PMID:  22261459     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
We report the case of a patient with myelodysplasia who had Sweet syndrome of the oral cavity. An atypical myeloid immunophenotype was present in the gingival biopsy specimen and in a concurrent bone marrow specimen. Fluorescence in situ hybridization performed on the gingival biopsy specimen demonstrated the same del(20q) cytogenetic abnormality present in the bone marrow, confirming the presence of a clonally related myeloid proliferation in both tissues. This is the first reported case of Sweet syndrome and myelodysplasia in which the chromosomal abnormality was identified in the neutrophilic infiltrate, confirming the neutrophilic infiltrate to be clonally related to the underlying myeloid neoplasm.
Authors:
Katherine Van Loon; Ryan M Gill; Patrick McMahon; Radhika Chigurupati; Imran Siddiqi; Lindy Fox; Lloyd Damon; Timothy H McCalmont; Richard Jordan; Jeffrey Wolf
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of clinical pathology     Volume:  137     ISSN:  1943-7722     ISO Abbreviation:  Am. J. Clin. Pathol.     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370470     Medline TA:  Am J Clin Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  310-5     Citation Subset:  AIM; IM    
Affiliation:
University of California, San Francisco, 505 Parnassus Ave, M1282, Box 1270, San Francisco, CA 94143.
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