Document Detail


201Tl-labelled TlCl dosimetry revisited.
MedLine Citation:
PMID:  8429986     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A review of the literature pertaining to the human dosimetry of 201Tl-labelled thallous chloride provides a spectrum of organ absorbed doses associated with this radiopharmaceutical. A more recent article details human quantitative studies up to 216 h postadministration. This multiorgan radiopharmacological study, however, reports the kidney dosimetry to be significantly lower than previous values; 0.0647 mGy MBq1 (0.238 rad mCi-1) compared to 0.326 mGy MBq-1 (1.2 rad mCi-1). Because of the latter discrepancy the dosimetry was recalculated using the reported pharmacodynamic data. This recalculation resulted in a kidney radiation dose comparable to previously published reports of 0.514 mGy MBq-1 (1.89 rad mCi-1). Also, revised absorbed doses to the various segments of the gastrointestinal tract (GIT) were significantly higher.
Authors:
F P Castronovo
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Nuclear medicine communications     Volume:  14     ISSN:  0143-3636     ISO Abbreviation:  Nucl Med Commun     Publication Date:  1993 Feb 
Date Detail:
Created Date:  1993-03-08     Completed Date:  1993-03-08     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8201017     Medline TA:  Nucl Med Commun     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  104-7     Citation Subset:  IM    
Affiliation:
Brigham and Women's Hospital, Department of Radiology, Harvard Medical School, Boston, MA 02115.
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MeSH Terms
Descriptor/Qualifier:
Humans
Radiation Dosage
Thallium / pharmacokinetics*
Thallium Radioisotopes / pharmacokinetics*
Tissue Distribution
Chemical
Reg. No./Substance:
0/Thallium Radioisotopes; 7440-28-0/Thallium; 7791-12-0/thallium chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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