Document Detail

20-hydroxyeicosatetraenoic acid, endothelial dysfunction and hypertension.
MedLine Citation:
PMID:  21849935     Owner:  NLM     Status:  MEDLINE    
20-hydroxyeicosatrienoic acid (20-HETE) is a metabolite of arachidonic acid formed by the enzymatic activity of cytochrome P450 omega hydroxylases of the 4A and 4F isoform families (CYP 450 4A and 4F). The role of the metabolites of arachidonic acid (AA) formed by cyclooxygenases and lipoxygenases in mediating cardiovascular function have been studied and known for a long time. More recently, particularly in the last 10-15 years, the importance of the role that the CYP450 omega hydroxylase/20-HETE system plays in cardiovascular, inflammatory and neoplastic diseases, has captured the attention of the scientific community. In this brief review we discuss some of the more recent findings related to the function of 20-HETE in the cardiovascular system. In particular we focus on the interactions of 20-HETE with the intracellular pathways of nitric oxide and the renin angiotensin system and discuss how it plays a role in oxidative stress, the development of endothelial dysfunction and experimental and human hypertension. To date the research strongly suggests that 20-HETE is an important and central mediator of cardiovascular function, and that alterations in the normal regulation of the CYP450/20-HETE system play a role in the pathogenesis of many disorders. There is great potential for the development of therapeutic agents to modify the activation and activity of this system in order to prevent and/or treat hypertension.
Mary Pat Kunert; Ines Drenjancević
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina     Volume:  8     ISSN:  1840-0132     ISO Abbreviation:  Med Glas (Zenica)     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-08-18     Completed Date:  2012-01-17     Revised Date:  2013-02-04    
Medline Journal Info:
Nlm Unique ID:  101250177     Medline TA:  Med Glas (Zenica)     Country:  Bosnia and Hercegovina    
Other Details:
Languages:  eng     Pagination:  170-80     Citation Subset:  IM    
College of Nursing, University of Wisconsin Milwaukee, WI 52311, USA.
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MeSH Terms
Cytochrome P-450 Enzyme System / physiology
Endothelium, Vascular / physiology*
Hydroxyeicosatetraenoic Acids / physiology*
Hypertension / physiopathology*
Nitric Oxide / physiology
Oxidative Stress / physiology
Renin-Angiotensin System / physiology
Reg. No./Substance:
0/Hydroxyeicosatetraenoic Acids; 10102-43-9/Nitric Oxide; 79551-86-3/20-hydroxy-5,8,11,14-eicosatetraenoic acid; 9035-51-2/Cytochrome P-450 Enzyme System

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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