| 20-hydroxyeicosatetraenoic acid, endothelial dysfunction and hypertension. | |
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MedLine Citation:
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PMID: 21849935 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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20-hydroxyeicosatrienoic acid (20-HETE) is a metabolite of arachidonic acid formed by the enzymatic activity of cytochrome P450 omega hydroxylases of the 4A and 4F isoform families (CYP 450 4A and 4F). The role of the metabolites of arachidonic acid (AA) formed by cyclooxygenases and lipoxygenases in mediating cardiovascular function have been studied and known for a long time. More recently, particularly in the last 10-15 years, the importance of the role that the CYP450 omega hydroxylase/20-HETE system plays in cardiovascular, inflammatory and neoplastic diseases, has captured the attention of the scientific community. In this brief review we discuss some of the more recent findings related to the function of 20-HETE in the cardiovascular system. In particular we focus on the interactions of 20-HETE with the intracellular pathways of nitric oxide and the renin angiotensin system and discuss how it plays a role in oxidative stress, the development of endothelial dysfunction and experimental and human hypertension. To date the research strongly suggests that 20-HETE is an important and central mediator of cardiovascular function, and that alterations in the normal regulation of the CYP450/20-HETE system play a role in the pathogenesis of many disorders. There is great potential for the development of therapeutic agents to modify the activation and activity of this system in order to prevent and/or treat hypertension. |
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Authors:
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Mary Pat Kunert; Ines Drenjancevic |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina Volume: 8 ISSN: 1840-0132 ISO Abbreviation: Med Glas Ljek komore Zenicko-doboj kantona Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-08-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101250177 Medline TA: Med Glas Ljek komore Zenicko-doboj kantona Country: Bosnia and Hercegovina |
Other Details:
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Languages: eng Pagination: 170-80 Citation Subset: IM |
Affiliation:
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1College of Nursing, University of Wisconsin Milwaukee, USA, 2Faculty of Medicine Osijek, University Josip Juraj Strossmayer, Osijek, Croatia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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