| 2-methoxylated fatty acids in marine sponges: defense mechanism against mycobacteria? | |
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MedLine Citation:
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PMID: 15588025 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A series of saturated 2-methoxylated FA having even-numbered chains with 8-14 carbons were synthesized, and their spectroscopic data are presented for the first time. The 2-methoxylated C10-C14 acids were prepared from the corresponding 2-hydroxylated FA, whereas the 2-methoxyoctanoic acid was synthesized starting with heptaldehyde. All of the methoxylated FA displayed some degree of inhibition (between 2 and 99%) of Mycobacterium tuberculosis H(37)Rv at 6.25 microg/mL. The most inhibitory FA was 2-methoxydecanoic acid, with a minimum inhibitory concentration of 200-239 microM against M. tuberculosis H(37)Rv as determined by both the microplate Alamar Blue assay and the green fluorescent protein microplate assay. These results are discussed in terms of the possible role of the 2-methoxylated FA as antimicrobial lipids produced either by marine sponges, or the associated marine symbiotic bacteria, as a defense mechanism in a highly competitive environment. |
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Authors:
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Néstor M Carballeira; Heidyleen Cruz; Cecil D Kwong; Baojie Wan; Scott Franzblau |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Lipids Volume: 39 ISSN: 0024-4201 ISO Abbreviation: Lipids Publication Date: 2004 Jul |
Date Detail:
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Created Date: 2004-12-13 Completed Date: 2005-07-05 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0060450 Medline TA: Lipids Country: United States |
Other Details:
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Languages: eng Pagination: 675-80 Citation Subset: IM |
Affiliation:
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Department of Chemistry, University of Puerto Rico, San Juan, Puerto Rico. ncarball@upracd.upr.clu.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Bacterial Agents / chemistry*, metabolism Fatty Acids / chemistry*, metabolism Molecular Structure Mycobacterium tuberculosis / metabolism* Porifera / chemistry*, microbiology* |
| Grant Support | |
ID/Acronym/Agency:
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S06GM08102/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Fatty Acids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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